TY - JOUR
T1 - Early Screening for the Parkinson Variant of Multiple System Atrophy
T2 - A 6-Item Score
AU - Fanciulli, Alessandra
AU - Stankovic, Iva
AU - Avraham, Omer
AU - Jecmenica Lukic, Milica
AU - Ezra, Adi
AU - Leys, Fabian
AU - Goebel, Georg
AU - Krismer, Florian
AU - Petrovic, Igor
AU - Svetel, Marina
AU - Seppi, Klaus
AU - Kostic, Vladimir
AU - Giladi, Nir
AU - Poewe, Werner
AU - Wenning, Gregor K.
AU - Gurevich, Tanya
N1 - Publisher Copyright:
© 2024 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
PY - 2024/7
Y1 - 2024/7
N2 - Background: A 4-item score based on ≥2 features out of orthostatic hypotension, overactive bladder, urinary retention and postural instability was previously shown to early distinguish the Parkinson-variant of multiple system atrophy (MSA-P) from Parkinson's disease (PD) with 78% sensitivity and 86% specificity. Objectives: To replicate and improve the 4-item MSA-P score. Methods: We retrospectively studied 161 patients with early parkinsonism [ie, ≤2 years disease duration or no postural instability, aged 64 (57; 68) years, 44% females] and a diagnosis of clinically established MSA-P (n = 38) or PD (n = 123) after ≥24 months follow-up. Results: The 4-item MSA-P score had a 92% sensitivity and 78% specificity for a final MSA-P diagnosis. By including dopaminergic responsiveness and postural deformities into a 6-item score (range: 0–6), reaching ≥3 points at early disease identified MSA-P patients with 89% sensitivity and 98% specificity. Conclusions: The 6-item MSA-P score is a cost-effective tool to pinpoint individuals with early-stage MSA-P.
AB - Background: A 4-item score based on ≥2 features out of orthostatic hypotension, overactive bladder, urinary retention and postural instability was previously shown to early distinguish the Parkinson-variant of multiple system atrophy (MSA-P) from Parkinson's disease (PD) with 78% sensitivity and 86% specificity. Objectives: To replicate and improve the 4-item MSA-P score. Methods: We retrospectively studied 161 patients with early parkinsonism [ie, ≤2 years disease duration or no postural instability, aged 64 (57; 68) years, 44% females] and a diagnosis of clinically established MSA-P (n = 38) or PD (n = 123) after ≥24 months follow-up. Results: The 4-item MSA-P score had a 92% sensitivity and 78% specificity for a final MSA-P diagnosis. By including dopaminergic responsiveness and postural deformities into a 6-item score (range: 0–6), reaching ≥3 points at early disease identified MSA-P patients with 89% sensitivity and 98% specificity. Conclusions: The 6-item MSA-P score is a cost-effective tool to pinpoint individuals with early-stage MSA-P.
KW - Parkinson's disease
KW - bladder dysfunction
KW - multiple system atrophy
KW - orthostatic hypotension
KW - postural instability
UR - http://www.scopus.com/inward/record.url?scp=85191351151&partnerID=8YFLogxK
U2 - 10.1002/mdc3.14048
DO - 10.1002/mdc3.14048
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C2 - 38659282
AN - SCOPUS:85191351151
SN - 2330-1619
VL - 11
SP - 867
EP - 873
JO - Movement Disorders Clinical Practice
JF - Movement Disorders Clinical Practice
IS - 7
ER -