Early myocardial deformation abnormalities in breast cancer survivors

Ben F. Bulten; Annelies M.C. Mavinkurve-Groothuis; Lioe Fee De Geus-Oei; Anton F.J. De Haan; Chris L. De Korte; Louise Bellersen; Hanneke W.M. Van Laarhoven; Livia Kapusta

doi:10.1007/s10549-014-2997-4

Early myocardial deformation abnormalities in breast cancer survivors

Ben F. Bulten^*, Annelies M.C. Mavinkurve-Groothuis, Lioe Fee De Geus-Oei, Anton F.J. De Haan, Chris L. De Korte, Louise Bellersen, Hanneke W.M. Van Laarhoven, Livia Kapusta

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

To evaluate the role of 2D myocardial strain (rate) imaging in the detection of early subclinical cardiotoxicity in breast cancer survivors treated with an anthracycline-based chemotherapeutic regimen. 57 adult breast cancer survivors were analyzed 1 year after therapy. All patients underwent biomarker analysis and 2D echocardiography consisting of conventional echocardiographic and strain (rate) parameters. Conventional echocardiographic values were normal. Global longitudinal strain was normal, but 18 % of patients showed a >2 SD decrease when individually compared to reference values. This subgroup showed a decrease in end-systolic and end-diastolic volumes and an increase in left ventricular mass. Radial and circumferential strain rates were significantly decreased in the whole study group. 2D myocardial strain (rate) imaging showed abnormalities in breast cancer survivors, while conventional echocardiographic values remained normal, rendering 2D myocardial strain (rate) imaging an interesting tool for the early detection of anthracycline-induced cardiotoxicity.

Original language	English
Pages (from-to)	127-135
Number of pages	9
Journal	Breast Cancer Research and Treatment
Volume	146
Issue number	1
DOIs	https://doi.org/10.1007/s10549-014-2997-4
State	Published - Jul 2014
Externally published	Yes

Funding

Funders	Funder number
Merck Sharp & Dohme B.V. and Sanofi-Aventis Netherlands B.V
Sanofi-Aventis Netherlands B.V.
Cephalon

Keywords

2D strain imaging
Anthracyclines
Biomarkers
Breast cancer
Echocardiography
Speckle tracking

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10.1007/s10549-014-2997-4

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title = "Early myocardial deformation abnormalities in breast cancer survivors",

abstract = "To evaluate the role of 2D myocardial strain (rate) imaging in the detection of early subclinical cardiotoxicity in breast cancer survivors treated with an anthracycline-based chemotherapeutic regimen. 57 adult breast cancer survivors were analyzed 1 year after therapy. All patients underwent biomarker analysis and 2D echocardiography consisting of conventional echocardiographic and strain (rate) parameters. Conventional echocardiographic values were normal. Global longitudinal strain was normal, but 18 % of patients showed a >2 SD decrease when individually compared to reference values. This subgroup showed a decrease in end-systolic and end-diastolic volumes and an increase in left ventricular mass. Radial and circumferential strain rates were significantly decreased in the whole study group. 2D myocardial strain (rate) imaging showed abnormalities in breast cancer survivors, while conventional echocardiographic values remained normal, rendering 2D myocardial strain (rate) imaging an interesting tool for the early detection of anthracycline-induced cardiotoxicity.",

keywords = "2D strain imaging, Anthracyclines, Biomarkers, Breast cancer, Echocardiography, Speckle tracking",

author = "Bulten, {Ben F.} and Mavinkurve-Groothuis, {Annelies M.C.} and {De Geus-Oei}, {Lioe Fee} and {De Haan}, {Anton F.J.} and {De Korte}, {Chris L.} and Louise Bellersen and {Van Laarhoven}, {Hanneke W.M.} and Livia Kapusta",

note = "Funding Information: Acknowledgments We kindly thank Caroline Mandigers and Har-ald Fliervoet for contributing to the enrollment of patients in our study. This study was financially supported by Cephalon B.V., Merck Sharp & Dohme B.V. and Sanofi-Aventis Netherlands B.V.",

year = "2014",

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doi = "10.1007/s10549-014-2997-4",

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volume = "146",

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journal = "Breast Cancer Research and Treatment",

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AU - Bulten, Ben F.

AU - Mavinkurve-Groothuis, Annelies M.C.

AU - De Geus-Oei, Lioe Fee

AU - De Haan, Anton F.J.

AU - De Korte, Chris L.

AU - Bellersen, Louise

AU - Van Laarhoven, Hanneke W.M.

AU - Kapusta, Livia

N1 - Funding Information: Acknowledgments We kindly thank Caroline Mandigers and Har-ald Fliervoet for contributing to the enrollment of patients in our study. This study was financially supported by Cephalon B.V., Merck Sharp & Dohme B.V. and Sanofi-Aventis Netherlands B.V.

PY - 2014/7

Y1 - 2014/7

N2 - To evaluate the role of 2D myocardial strain (rate) imaging in the detection of early subclinical cardiotoxicity in breast cancer survivors treated with an anthracycline-based chemotherapeutic regimen. 57 adult breast cancer survivors were analyzed 1 year after therapy. All patients underwent biomarker analysis and 2D echocardiography consisting of conventional echocardiographic and strain (rate) parameters. Conventional echocardiographic values were normal. Global longitudinal strain was normal, but 18 % of patients showed a >2 SD decrease when individually compared to reference values. This subgroup showed a decrease in end-systolic and end-diastolic volumes and an increase in left ventricular mass. Radial and circumferential strain rates were significantly decreased in the whole study group. 2D myocardial strain (rate) imaging showed abnormalities in breast cancer survivors, while conventional echocardiographic values remained normal, rendering 2D myocardial strain (rate) imaging an interesting tool for the early detection of anthracycline-induced cardiotoxicity.

AB - To evaluate the role of 2D myocardial strain (rate) imaging in the detection of early subclinical cardiotoxicity in breast cancer survivors treated with an anthracycline-based chemotherapeutic regimen. 57 adult breast cancer survivors were analyzed 1 year after therapy. All patients underwent biomarker analysis and 2D echocardiography consisting of conventional echocardiographic and strain (rate) parameters. Conventional echocardiographic values were normal. Global longitudinal strain was normal, but 18 % of patients showed a >2 SD decrease when individually compared to reference values. This subgroup showed a decrease in end-systolic and end-diastolic volumes and an increase in left ventricular mass. Radial and circumferential strain rates were significantly decreased in the whole study group. 2D myocardial strain (rate) imaging showed abnormalities in breast cancer survivors, while conventional echocardiographic values remained normal, rendering 2D myocardial strain (rate) imaging an interesting tool for the early detection of anthracycline-induced cardiotoxicity.

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KW - Anthracyclines

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KW - Breast cancer

KW - Echocardiography

KW - Speckle tracking

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Early myocardial deformation abnormalities in breast cancer survivors

Abstract

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Keywords

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