Early events in the assembly of E-cadherin adhesions

Kabir H. Biswas; Ronen Zaidel-Bar

doi:10.1016/j.yexcr.2017.02.037

Early events in the assembly of E-cadherin adhesions

Kabir H. Biswas^*, Ronen Zaidel-Bar

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

E-cadherin is a calcium dependent cell adhesion molecule that is key to the organization of cells in the epithelial tissue. It is a multidomain, trans-membrane protein in which the extracellular domain forms the homotypic, adhesive interaction while the intracellular domain interacts with the actin cytoskeleton through the catenin family of adaptor proteins. A number of recent studies have provided novel insights into the mechanism of adhesion formation by this class of adhesion proteins. Here, we describe an updated view of the process of E-cadherin adhesion formation with an emphasis on the role of molecular mobility, clustering, and active cellular processes.

Original language	English
Pages (from-to)	14-19
Number of pages	6
Journal	Experimental Cell Research
Volume	358
Issue number	1
DOIs	https://doi.org/10.1016/j.yexcr.2017.02.037
State	Published - 1 Sep 2017
Externally published	Yes

Keywords

Cadherin
Catenin
Cell-cell adhesion
Clustering
Cytoskeleton
Diffusion
Filopodia

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10.1016/j.yexcr.2017.02.037

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AB - E-cadherin is a calcium dependent cell adhesion molecule that is key to the organization of cells in the epithelial tissue. It is a multidomain, trans-membrane protein in which the extracellular domain forms the homotypic, adhesive interaction while the intracellular domain interacts with the actin cytoskeleton through the catenin family of adaptor proteins. A number of recent studies have provided novel insights into the mechanism of adhesion formation by this class of adhesion proteins. Here, we describe an updated view of the process of E-cadherin adhesion formation with an emphasis on the role of molecular mobility, clustering, and active cellular processes.

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KW - Catenin

KW - Cell-cell adhesion

KW - Clustering

KW - Cytoskeleton

KW - Diffusion

KW - Filopodia

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Early events in the assembly of E-cadherin adhesions

Abstract

Keywords

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