Early events in the assembly of E-cadherin adhesions

Kabir H. Biswas*, Ronen Zaidel-Bar

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


E-cadherin is a calcium dependent cell adhesion molecule that is key to the organization of cells in the epithelial tissue. It is a multidomain, trans-membrane protein in which the extracellular domain forms the homotypic, adhesive interaction while the intracellular domain interacts with the actin cytoskeleton through the catenin family of adaptor proteins. A number of recent studies have provided novel insights into the mechanism of adhesion formation by this class of adhesion proteins. Here, we describe an updated view of the process of E-cadherin adhesion formation with an emphasis on the role of molecular mobility, clustering, and active cellular processes.

Original languageEnglish
Pages (from-to)14-19
Number of pages6
JournalExperimental Cell Research
Issue number1
StatePublished - 1 Sep 2017
Externally publishedYes


  • Cadherin
  • Catenin
  • Cell-cell adhesion
  • Clustering
  • Cytoskeleton
  • Diffusion
  • Filopodia


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