Early Diagnosis of Bladder Exstrophy Quantitative Assessment of a Low-Inserted Umbilical Cord

Michal Fishel-Bartal, Sharon Perlman*, Baruch Messing, Ron Bardin, Zvi Kivilevitch, Reuven Achiron, Yinon Gilboa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives—Bladder exstrophy is a rare severe congenital malformation. Early prenatal diagnosis is scarcely described in the literature. Low insertion of the umbilical cord is a constant anatomic feature of bladder exstrophy. The aim of our study was to assess whether early measurements of the umbilical cord insertion–to–genital tubercle length may serve as quantitative measurements for a low-inserted umbilical cord in cases of bladder exstrophy. Methods—The umbilical cord insertion–to–genital tubercle length was prospec-tively measured in all cases referred for a nonvisualized urinary bladder before 18 weeks’ gestation. Final diagnoses were compared with prenatal measurements. Results—Fifteen fetuses were evaluated for a nonvisualized bladder at a mean gesta-tional age of 15.7 weeks (range, 14–17 weeks). Of them, 6 cases were diagnosed with bladder exstrophy, and 9 cases had a normal urinary bladder. All cases with bladder exstrophy had an umbilical cord insertion–to–genital tubercle length below the fifth percentile for gestational age, whereas cases with a normal bladder had a normal measurement. Conclusions—Fetuses with bladder exstrophy have an umbilical cord insertion–to– genital tubercle length below the fifth percentile of the general population. This measurement may serve as a complementary objective sonographic parameter in the prenatal assessment and counseling of cases suspected of having bladder exstro-phy during early pregnancy.

Original languageEnglish
Pages (from-to)1801-1805
Number of pages5
JournalJournal of Ultrasound in Medicine
Volume36
Issue number9
DOIs
StatePublished - Sep 2017

Keywords

  • bladder exstrophy
  • early prenatal diagnosis
  • low-inserted umbilical cord
  • obstetric ultrasound

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