Early detection of a circulating pre-vaccine-derived poliovirus type 1 (pre-VDPV1) variant linked to an acute flaccid polio case prior to VDPV1 emergence, Israel, 2024 to 2025

  • Neta S. Zuckerman
  • , Yaniv Lustig
  • , Danit Sofer
  • , Lester M. Shulman
  • , Leah Weiss
  • , Rinat Vasserman
  • , Reut Gabai
  • , Keren Friedman
  • , Hagar Eliyahu
  • , Noa Bar-Liss
  • , Tatyana Kushnir
  • , Ira Aguvaev
  • , Tal Butensky
  • , Daniel Avhar
  • , Alex Aydenzon
  • , Oran Erster
  • , Itay Bar-Or
  • , Merav Weil*
  • *Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We report the emergence and evolution of a circulating vaccine-derived poliovirus type 1 (cVDPV1) outbreak in Israel, linked to a vaccine-associated paralytic poliomyelitis case. Whole genome sequencing revealed a strong genetic link between the Sabin-like poliovirus type 1 variant from the case and pre-VDPV1 and VDPV1 isolated from environmental samples collected in October 2024–April 2025, mostly in Jerusalem. Early detection was made possible by Israel’s robust environmental surveillance and advanced sequencing technologies, enabling a rapid public health response.

Original languageEnglish
Article numberpii=2500605
JournalEurosurveillance
Volume30
Issue number34
DOIs
StatePublished - 28 Aug 2025

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