E23D: Database and visualization of A-to-I RNA editing sites mapped to 3D protein structures

Oz Solomon*, Eran Eyal, Ninette Amariglio, Ron Unger, Gidi Rechavi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

e23D, a database of A-to-I RNA editing sites from human, mouse and fly mapped to evolutionary related protein 3D structures, is presented. Genomic coordinates of A-to-I RNA editing sites are converted to protein coordinates and mapped onto 3D structures from PDB or theoretical models from ModBase. e23D allows visualization of the protein structure, modeling of recoding events and orientation of the editing with respect to nearby genomic functional sites from databases of disease causing mutations and genomic polymorphism. Availability and Implementation: http://www.sheba-cancer.org.il/e23D Contact: or Eran.Eyal@sheba.health.gov.il.

Original languageEnglish
Pages (from-to)2213-2215
Number of pages3
JournalBioinformatics
Volume32
Issue number14
DOIs
StatePublished - 15 Jul 2016

Funding

FundersFunder number
Israeli Centers of Excellence
Varda and Boaz Dotan Research Center
Flight Attendant Medical Research Institute
Israel Science Foundation41/11, 1796/12
Tel Aviv University
Israeli Centers for Research Excellence

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