E-cadherin complex protein expression and survival in ovarian carcinoma

Ben Davidson*, Walter H. Gotlieb, Gilad Ben-Baruch, Jahn M. Nesland, Magne Bryne, Iris Goldberg, Juri Kopolovic, Aasmund Berner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective. The aim of this study was to analyze the correlation between expression of E-cadherin complex proteins, epidermal growth factor receptor (EGFR), and c-erbB-2 and disease outcome in advanced-stage ovarian carcinomas. Methods. Sections from 75 primary ovarian carcinomas (=37) and metastatic lesions (=38) from 45 patients diagnosed with advanced-stage ovarian carcinoma (FIGO stage III-IV) were immunostained and evaluated for staining pattern, extent, and intensity. Patients were divided in two groups based on disease outcome. Long-term survivors (21 patients) and short-term survivors (24 patients) were defined using a double cutoff of 36 months for disease-free survival (DFS) and 60 months for overall survival (OS). Mean follow-up period was 70 months. The mean values for DFS and as were 109 and 125 months for long-term survivors, as compared to 3 and 21 months for short-term survivors, respectively. Results. Comparison of all primary and metastatic lesions showed upregulation of γ-catenin protein expression in the latter (P = 0.05). When segregated according to disease outcome, the expression of all studied proteins, with the exception of EGFR, was more diffuse in tumors of short-term survivors. The presence of cytoplasmic staining for c-erbB-2 was associated with poor survival in the entire cohort (P = 0.007), as well as in primary tumors alone (P = 0.003), in survival analysis. Similar results were seen in the evaluation of primary tumors for γ-catenin (P = 0.002). Conclusions. γ-Catenin, and possibly c-erbB-2, are valid markers of poor survival in advanced-stage ovarian carcinoma. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)362-371
Number of pages10
JournalGynecologic Oncology
Issue number3
StatePublished - 2000


  • Disease outcome
  • E-cadherin
  • Epidermal growth factor receptor
  • Immunohistochemistry
  • Ovarian carcinoma
  • c-erbB-2
  • α-catenin
  • β-catenin
  • γ-catenin


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