Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: Lack of association with clinical phenotypes

Neslihan Aygun Kocabas, Irina Antonijevic, Carole Faghel, Carlos Forray, Siegfried Kasper, Yves Lecrubier, Sylvie Linotte, Isabelle Massat, Stuart Montgomery, Magali Noro, Pierre Oswald, Lenore Snyder, Daniel Souery, Joseph Zohar, Julien Mendlewicz

Research output: Contribution to journalArticlepeer-review


Objectives. Dystrobrevin binding protein 1 (Dysbindin) is a plausible candidate gene for major depressive disorders (MDD) due to its involvement in synaptic signaling, plasticity and localization in the brain. Methods. Two intronic SNPs of DTNBP1; rs760761 (P1320) and rs2619522 (P1763) were analyzed in 206 patients with DSM-IV MDD to investigate the functional impact of genotypes on susceptibility for depression and some clinical phenotypes. The Sequenom iPLEX assay (Sequenom, Cambridge, MA) was used for genotyping. Results and Conclusions. Despite the limited power of analysis, our results showed that these two SNPs in DTNPB1 gene were not related to clinical phenotypes such as melancholia, age at onset, suicidality and co-morbid anxiety disorders, as well as to treatment response phenotypes.

Original languageEnglish
Pages (from-to)985-990
Number of pages6
JournalWorld Journal of Biological Psychiatry
Issue number8
StatePublished - Dec 2010
Externally publishedYes


  • DTNBP1 (dystrobrevin binding protein 1)
  • SNP
  • clinical phenotypes
  • major depressive disorder (MDD)
  • treatment response


Dive into the research topics of 'Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: Lack of association with clinical phenotypes'. Together they form a unique fingerprint.

Cite this