Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: Lack of association with clinical phenotypes

Neslihan Aygun Kocabas; Irina Antonijevic; Carole Faghel; Carlos Forray; Siegfried Kasper; Yves Lecrubier; Sylvie Linotte; Isabelle Massat; Stuart Montgomery; Magali Noro; Pierre Oswald; Lenore Snyder; Daniel Souery; Joseph Zohar; Julien Mendlewicz

doi:10.3109/15622975.2010.512089

Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: Lack of association with clinical phenotypes

Neslihan Aygun Kocabas, Irina Antonijevic, Carole Faghel, Carlos Forray, Siegfried Kasper, Yves Lecrubier, Sylvie Linotte, Isabelle Massat, Stuart Montgomery, Magali Noro, Pierre Oswald, Lenore Snyder, Daniel Souery, Joseph Zohar, Julien Mendlewicz

Research output: Contribution to journal › Article › peer-review

Abstract

Objectives. Dystrobrevin binding protein 1 (Dysbindin) is a plausible candidate gene for major depressive disorders (MDD) due to its involvement in synaptic signaling, plasticity and localization in the brain. Methods. Two intronic SNPs of DTNBP1; rs760761 (P1320) and rs2619522 (P1763) were analyzed in 206 patients with DSM-IV MDD to investigate the functional impact of genotypes on susceptibility for depression and some clinical phenotypes. The Sequenom iPLEX assay (Sequenom, Cambridge, MA) was used for genotyping. Results and Conclusions. Despite the limited power of analysis, our results showed that these two SNPs in DTNPB1 gene were not related to clinical phenotypes such as melancholia, age at onset, suicidality and co-morbid anxiety disorders, as well as to treatment response phenotypes.

Original language	English
Pages (from-to)	985-990
Number of pages	6
Journal	World Journal of Biological Psychiatry
Volume	11
Issue number	8
DOIs	https://doi.org/10.3109/15622975.2010.512089
State	Published - Dec 2010
Externally published	Yes

Keywords

DTNBP1 (dystrobrevin binding protein 1)
SNP
clinical phenotypes
major depressive disorder (MDD)
treatment response

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/15622975.2010.512089

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Kocabas, N. A., Antonijevic, I., Faghel, C., Forray, C., Kasper, S., Lecrubier, Y., Linotte, S., Massat, I., Montgomery, S., Noro, M., Oswald, P., Snyder, L., Souery, D., Zohar, J., & Mendlewicz, J. (2010). Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: Lack of association with clinical phenotypes. World Journal of Biological Psychiatry, 11(8), 985-990. https://doi.org/10.3109/15622975.2010.512089

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title = "Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: Lack of association with clinical phenotypes",

abstract = "Objectives. Dystrobrevin binding protein 1 (Dysbindin) is a plausible candidate gene for major depressive disorders (MDD) due to its involvement in synaptic signaling, plasticity and localization in the brain. Methods. Two intronic SNPs of DTNBP1; rs760761 (P1320) and rs2619522 (P1763) were analyzed in 206 patients with DSM-IV MDD to investigate the functional impact of genotypes on susceptibility for depression and some clinical phenotypes. The Sequenom iPLEX assay (Sequenom, Cambridge, MA) was used for genotyping. Results and Conclusions. Despite the limited power of analysis, our results showed that these two SNPs in DTNPB1 gene were not related to clinical phenotypes such as melancholia, age at onset, suicidality and co-morbid anxiety disorders, as well as to treatment response phenotypes.",

keywords = "DTNBP1 (dystrobrevin binding protein 1), SNP, clinical phenotypes, major depressive disorder (MDD), treatment response",

author = "Kocabas, {Neslihan Aygun} and Irina Antonijevic and Carole Faghel and Carlos Forray and Siegfried Kasper and Yves Lecrubier and Sylvie Linotte and Isabelle Massat and Stuart Montgomery and Magali Noro and Pierre Oswald and Lenore Snyder and Daniel Souery and Joseph Zohar and Julien Mendlewicz",

note = "Funding Information: We are grateful to all study participants. This study was supported by a grant from the Belgian National Fund for Scientific Research (FNRS; 3.4.530.07 F) and from an unrestricted grant from Lundbeck A/S to the Group for the Study of the Resistant Depression (GSRD).",

year = "2010",

month = dec,

doi = "10.3109/15622975.2010.512089",

language = "אנגלית",

volume = "11",

pages = "985--990",

journal = "World Journal of Biological Psychiatry",

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Kocabas, NA, Antonijevic, I, Faghel, C, Forray, C, Kasper, S, Lecrubier, Y, Linotte, S, Massat, I, Montgomery, S, Noro, M, Oswald, P, Snyder, L, Souery, D, Zohar, J & Mendlewicz, J 2010, 'Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: Lack of association with clinical phenotypes', World Journal of Biological Psychiatry, vol. 11, no. 8, pp. 985-990. https://doi.org/10.3109/15622975.2010.512089

TY - JOUR

T1 - Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients

T2 - Lack of association with clinical phenotypes

AU - Kocabas, Neslihan Aygun

AU - Antonijevic, Irina

AU - Faghel, Carole

AU - Forray, Carlos

AU - Kasper, Siegfried

AU - Lecrubier, Yves

AU - Linotte, Sylvie

AU - Massat, Isabelle

AU - Montgomery, Stuart

AU - Noro, Magali

AU - Oswald, Pierre

AU - Snyder, Lenore

AU - Souery, Daniel

AU - Zohar, Joseph

AU - Mendlewicz, Julien

N1 - Funding Information: We are grateful to all study participants. This study was supported by a grant from the Belgian National Fund for Scientific Research (FNRS; 3.4.530.07 F) and from an unrestricted grant from Lundbeck A/S to the Group for the Study of the Resistant Depression (GSRD).

PY - 2010/12

Y1 - 2010/12

N2 - Objectives. Dystrobrevin binding protein 1 (Dysbindin) is a plausible candidate gene for major depressive disorders (MDD) due to its involvement in synaptic signaling, plasticity and localization in the brain. Methods. Two intronic SNPs of DTNBP1; rs760761 (P1320) and rs2619522 (P1763) were analyzed in 206 patients with DSM-IV MDD to investigate the functional impact of genotypes on susceptibility for depression and some clinical phenotypes. The Sequenom iPLEX assay (Sequenom, Cambridge, MA) was used for genotyping. Results and Conclusions. Despite the limited power of analysis, our results showed that these two SNPs in DTNPB1 gene were not related to clinical phenotypes such as melancholia, age at onset, suicidality and co-morbid anxiety disorders, as well as to treatment response phenotypes.

AB - Objectives. Dystrobrevin binding protein 1 (Dysbindin) is a plausible candidate gene for major depressive disorders (MDD) due to its involvement in synaptic signaling, plasticity and localization in the brain. Methods. Two intronic SNPs of DTNBP1; rs760761 (P1320) and rs2619522 (P1763) were analyzed in 206 patients with DSM-IV MDD to investigate the functional impact of genotypes on susceptibility for depression and some clinical phenotypes. The Sequenom iPLEX assay (Sequenom, Cambridge, MA) was used for genotyping. Results and Conclusions. Despite the limited power of analysis, our results showed that these two SNPs in DTNPB1 gene were not related to clinical phenotypes such as melancholia, age at onset, suicidality and co-morbid anxiety disorders, as well as to treatment response phenotypes.

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VL - 11

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JF - World Journal of Biological Psychiatry

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ER -

Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: Lack of association with clinical phenotypes

Abstract

Keywords

UN SDGs

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