Dynamic protein allosteric regulation and disease

Ruth Nussinov*, Chung Jung Tsai, Hyunbum Jang

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Allostery is largely associated with conformational and functional transitions in individual proteins. All dynamic proteins are allosteric. This concept can be extended to consider the impact of conformational perturbations on cellular function and disease states. In this section, we will illuminate how allostery can control physiological activities and cause disease, aiming to increase the awareness of the linkage between disease symptoms on the cellular level and specific aberrant allosteric actions on the molecular level.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages19
StatePublished - 2019

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Cell organization
  • Cell signaling
  • Cell structure
  • Diffusion
  • Signal transduction
  • Signaling modules
  • Signaling pathways


Dive into the research topics of 'Dynamic protein allosteric regulation and disease'. Together they form a unique fingerprint.

Cite this