Dynamic protein allosteric regulation and disease

Ruth Nussinov; Chung Jung Tsai; Hyunbum Jang

doi:10.1007/978-981-13-8719-7_2

Dynamic protein allosteric regulation and disease

Ruth Nussinov^*, Chung Jung Tsai, Hyunbum Jang

^*Corresponding author for this work

Human Molecular Genetics Biochemistry

Leidos Inc

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

16 Scopus citations

Abstract

Allostery is largely associated with conformational and functional transitions in individual proteins. All dynamic proteins are allosteric. This concept can be extended to consider the impact of conformational perturbations on cellular function and disease states. In this section, we will illuminate how allostery can control physiological activities and cause disease, aiming to increase the awareness of the linkage between disease symptoms on the cellular level and specific aberrant allosteric actions on the molecular level.

Original language	English
Title of host publication	Advances in Experimental Medicine and Biology
Publisher	Springer
Pages	25-43
Number of pages	19
DOIs	https://doi.org/10.1007/978-981-13-8719-7_2
State	Published - 2019

Publication series

Name	Advances in Experimental Medicine and Biology
Volume	1163
ISSN (Print)	0065-2598
ISSN (Electronic)	2214-8019

Keywords

Cell organization
Cell signaling
Cell structure
Diffusion
Signal transduction
Signaling modules
Signaling pathways

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-981-13-8719-7_2

Cite this

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KW - Diffusion

KW - Signal transduction

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KW - Signaling pathways

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Dynamic protein allosteric regulation and disease

Abstract

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Keywords

UN SDGs

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