Dynamic formation of multiple preconcentrated molecule plugs

Barak Sabbagh, Elad Stolovicki, Sinwook Park, Gilad Yossifon

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Integration of ionic permselective medium (e.g. nanochannels) within microfluidic channels has been shown to enable verity of on-chip applications, such as biomolecule preconcentration for enhanced biosensing sensitivity. Herein, we able to dynamically control the ion-permselective medium, which introduces a new functionality into microfluidic based lab-on-a-chip devices, e.g. multiplex detection where a preconcentrated plug of biomolecules can be dynamically located at different sensing regions. In addition, we show that the ability to simultaneously form a series of preconcentrated plugs increase parallelization of the system and trapping efficiency of target analytes.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages262-263
Number of pages2
ISBN (Electronic)9781733419017
StatePublished - 2020
Externally publishedYes
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: 4 Oct 20209 Oct 2020

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period4/10/209/10/20

Keywords

  • Concentration-polarization
  • Ion perm-selectivity
  • Nanochannel
  • Preconcentration

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