Dynamic equilibrium between multiple active and inactive conformations explains regulation and oncogenic mutations in ErbB receptors

Keyphrases

• Oncogenic mutations 100%
• Active Conformation 100%
• Inactive Conformation 100%
• ErbB Receptors 100%
• ErbB 100%
• Dynamic Equilibrium 100%
• ErbB2 50%
• Intracellular Domain 50%
• Extracellular Domain 50%
• ErbB1 50%
• Kinase Domain 25%
• Membrane Protein 25%
• Genetic Data 25%
• Family Members 25%
• Physiological Processes 25%
• Suggested Model 25%
• Regulatory Mechanism 25%
• Structural Information 25%
• Pathological Process 25%
• Activation Mechanism 25%
• Receptor Tyrosine Kinase 25%
• Sequence Modification 25%
• Growth Hormone Receptor 25%
• Active State 25%
• Transmembrane 25%
• Ligand Binding Affinity 25%
• Activation State 25%
• Phylogenetic Information 25%
• Biochemical Data 25%
• Asymmetric Dimer 25%
• Oncogenic Alterations 25%
• Computational Data 25%
• Aberrant Signaling 25%
• Biophysical Data 25%

Biochemistry, Genetics and Molecular Biology

• Conformation 100%
• Carcinogenesis 100%
• Epidermal Growth Factor Receptor 100%
• ErbB 66%
• Crystal Structure 33%
• Binding Affinity 33%
• Genetics 33%
• Kinase 33%
• Phosphotransferase 33%
• Gene Mutation 33%
• Receptor Tyrosine Kinase 33%
• Ligand Binding 33%
• Growth Factor Receptor 33%