DWI and Breast Physiology Status

Noam Nissan, Debbie Anaby, Ethan Bauer, Miri Sklair-Levy

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The normal breast parenchyma undergoes marked alterations in response to different hormonal states, from puberty onset and fluctuations in the menstrual cycle through pregnancy, lactation, and menopause. Diffusion-weighted imaging (DWI) holds the potential to not only improve the diagnosis and biological characterization of breast cancer but also probe the physiological changes in the water-diffusion process within the healthy fibroglandular tissue and provide a noninvasive imaging means to track functional and microstructural processes in this dynamic organ. As opposed to other imaging modalities, in particular dynamic contrast-enhanced magnetic resonance imaging (DCE MRI), the diffusivity changes in different hormonal states seem negligible from a clinical standpoint. The immunity of DWI to many of the hormonal-induced drawbacks of breast imaging suggests an opportunity for this method to obtain a larger clinical role in these settings.

Original languageEnglish
Title of host publicationDiffusion MRI of the Breast
Number of pages8
ISBN (Electronic)9780323797023
ISBN (Print)9780323811026
StatePublished - 1 Jan 2022
Externally publishedYes


  • PABC imaging
  • breast diffusion-weighted imaging
  • breast hormonal regulation
  • diffusion MRI
  • lactation MRI


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