Duodenal epithelial atypia. A specific complication of hepatic arterial infusion chemotherapy

Lucia Schuger; Tamar Peretz; Eran Goldin; Arie L. Durst; Elimelech Okon

doi:10.1002/1097-0142(19880215)61:4<663::AID-CNCR2820610408>3.0.CO;2-R

Duodenal epithelial atypia. A specific complication of hepatic arterial infusion chemotherapy

Lucia Schuger, Tamar Peretz, Eran Goldin, Arie L. Durst, Elimelech Okon^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Severe duodenal lesions developed in five patients during hepatic arterial infusion (HAI) employing 5‐floxuridine (FUDR) as the basic antineoplastic agent. These lesions comprised ulcerative as well as proliferative processes. Striking structural distortion with cellular pleomorphism of the affected duodenal mucosa were the histological hallmark in all cases. These lesions are a specific complication of HAI chemotherapy and should not be misinterpreted as malignancy.

Original language	English
Pages (from-to)	663-666
Number of pages	4
Journal	Cancer
Volume	61
Issue number	4
DOIs	https://doi.org/10.1002/1097-0142(19880215)61:4<663::AID-CNCR2820610408>3.0.CO;2-R
State	Published - 15 Feb 1988
Externally published	Yes

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10.1002/1097-0142(19880215)61:4<663::AID-CNCR2820610408>3.0.CO;2-R

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AU - Peretz, Tamar

AU - Goldin, Eran

AU - Durst, Arie L.

AU - Okon, Elimelech

PY - 1988/2/15

Y1 - 1988/2/15

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AB - Severe duodenal lesions developed in five patients during hepatic arterial infusion (HAI) employing 5‐floxuridine (FUDR) as the basic antineoplastic agent. These lesions comprised ulcerative as well as proliferative processes. Striking structural distortion with cellular pleomorphism of the affected duodenal mucosa were the histological hallmark in all cases. These lesions are a specific complication of HAI chemotherapy and should not be misinterpreted as malignancy.

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Duodenal epithelial atypia. A specific complication of hepatic arterial infusion chemotherapy

Abstract

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