Dual regulation by opioids of 3H-norepinephrine release in the human neuroblastoma cell-line SK-N-SH

O. Keren; M. Garty; Y. Sarne

doi:10.1016/0006-8993(94)90098-1

Dual regulation by opioids of ³H-norepinephrine release in the human neuroblastoma cell-line SK-N-SH

O. Keren, M. Garty, Y. Sarne

Physiology Pharmacology

Research output: Contribution to journal › Article › peer-review

Abstract

Depolarization-evoked ³H-norepinephrine release from SK-N-SH cells was found to be regulated by opioid ligands. Opioids excerted either inhibition or augmentation of ³H-norepinephrine release. Both effects were mediated by opioid receptors. In addition, a nonopioid inhibitory effect of opiates on release was observed. The SK-N-SH cell-line provides a suitable model for studying the various mechanisms underlying the opioid regulatory pathways within single cells.

Original language	English
Pages (from-to)	319-323
Number of pages	5
Journal	Brain Research
Volume	646
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(94)90098-1
State	Published - 23 May 1994

Keywords

Catecholamine
Neurotransmitter release
Norepinephrine
Opioid receptor
SK-N-SH cell

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10.1016/0006-8993(94)90098-1

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title = "Dual regulation by opioids of 3H-norepinephrine release in the human neuroblastoma cell-line SK-N-SH",

abstract = "Depolarization-evoked 3H-norepinephrine release from SK-N-SH cells was found to be regulated by opioid ligands. Opioids excerted either inhibition or augmentation of 3H-norepinephrine release. Both effects were mediated by opioid receptors. In addition, a nonopioid inhibitory effect of opiates on release was observed. The SK-N-SH cell-line provides a suitable model for studying the various mechanisms underlying the opioid regulatory pathways within single cells.",

keywords = "Catecholamine, Neurotransmitter release, Norepinephrine, Opioid receptor, SK-N-SH cell",

author = "O. Keren and M. Garty and Y. Sarne",

note = "Funding Information: This research was supported by a grant from the Anti-Drug Authority of Israel.",

year = "1994",

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AU - Keren, O.

AU - Garty, M.

AU - Sarne, Y.

N1 - Funding Information: This research was supported by a grant from the Anti-Drug Authority of Israel.

PY - 1994/5/23

Y1 - 1994/5/23

N2 - Depolarization-evoked 3H-norepinephrine release from SK-N-SH cells was found to be regulated by opioid ligands. Opioids excerted either inhibition or augmentation of 3H-norepinephrine release. Both effects were mediated by opioid receptors. In addition, a nonopioid inhibitory effect of opiates on release was observed. The SK-N-SH cell-line provides a suitable model for studying the various mechanisms underlying the opioid regulatory pathways within single cells.

AB - Depolarization-evoked 3H-norepinephrine release from SK-N-SH cells was found to be regulated by opioid ligands. Opioids excerted either inhibition or augmentation of 3H-norepinephrine release. Both effects were mediated by opioid receptors. In addition, a nonopioid inhibitory effect of opiates on release was observed. The SK-N-SH cell-line provides a suitable model for studying the various mechanisms underlying the opioid regulatory pathways within single cells.

KW - Catecholamine

KW - Neurotransmitter release

KW - Norepinephrine

KW - Opioid receptor

KW - SK-N-SH cell

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ER -

Dual regulation by opioids of ³H-norepinephrine release in the human neuroblastoma cell-line SK-N-SH

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