Dual regulation by opioids of 3H-norepinephrine release in the human neuroblastoma cell-line SK-N-SH

O. Keren, M. Garty, Y. Sarne

Research output: Contribution to journalArticlepeer-review

Abstract

Depolarization-evoked 3H-norepinephrine release from SK-N-SH cells was found to be regulated by opioid ligands. Opioids excerted either inhibition or augmentation of 3H-norepinephrine release. Both effects were mediated by opioid receptors. In addition, a nonopioid inhibitory effect of opiates on release was observed. The SK-N-SH cell-line provides a suitable model for studying the various mechanisms underlying the opioid regulatory pathways within single cells.

Original languageEnglish
Pages (from-to)319-323
Number of pages5
JournalBrain Research
Volume646
Issue number2
DOIs
StatePublished - 23 May 1994

Keywords

  • Catecholamine
  • Neurotransmitter release
  • Norepinephrine
  • Opioid receptor
  • SK-N-SH cell

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