Dual effect of synthetic aminoglycosides: Antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor

Micha Fridman, Valery Belakhov, Lac V. Lee, Fu Sen Liang, Chi Huey Wong, Timor Baasov

Research output: Contribution to journalArticlepeer-review

Abstract

Defence against bioterrorism: Recent events have created an urgent need for therapeutic strategies to treat anthrax, an infectious disease caused by the toxigenic bacterium Bacillus anthracis. A new class of aminoglycosides (see picture) are powerful inhibitors under physiological conditions of the anthrax lethal factor, which has a major role in the disease, and function simultaneously as antibiotics against B. anthracis. (Chemical Equation Presented).

Original languageEnglish
Pages (from-to)447-452
Number of pages6
JournalAngewandte Chemie - International Edition
Volume44
Issue number3
DOIs
StatePublished - 3 Jan 2005
Externally publishedYes

Keywords

  • Aminoglycosides
  • Anthrax
  • Antibiotics
  • Inhibitors

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