Dual effect of synthetic aminoglycosides: Antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor

Micha Fridman; Valery Belakhov; Lac V. Lee; Fu Sen Liang; Chi Huey Wong; Timor Baasov

doi:10.1002/anie.200462003

Dual effect of synthetic aminoglycosides: Antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor

Micha Fridman, Valery Belakhov, Lac V. Lee, Fu Sen Liang, Chi Huey Wong^*, Timor Baasov

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

Defence against bioterrorism: Recent events have created an urgent need for therapeutic strategies to treat anthrax, an infectious disease caused by the toxigenic bacterium Bacillus anthracis. A new class of aminoglycosides (see picture) are powerful inhibitors under physiological conditions of the anthrax lethal factor, which has a major role in the disease, and function simultaneously as antibiotics against B. anthracis. (Chemical Equation Presented).

Original language	English
Pages (from-to)	447-452
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	44
Issue number	3
DOIs	https://doi.org/10.1002/anie.200462003
State	Published - 3 Jan 2005
Externally published	Yes

Keywords

Aminoglycosides
Anthrax
Antibiotics
Inhibitors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/anie.200462003

Cite this

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abstract = "Defence against bioterrorism: Recent events have created an urgent need for therapeutic strategies to treat anthrax, an infectious disease caused by the toxigenic bacterium Bacillus anthracis. A new class of aminoglycosides (see picture) are powerful inhibitors under physiological conditions of the anthrax lethal factor, which has a major role in the disease, and function simultaneously as antibiotics against B. anthracis. (Chemical Equation Presented).",

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AU - Lee, Lac V.

AU - Liang, Fu Sen

AU - Wong, Chi Huey

AU - Baasov, Timor

PY - 2005/1/3

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AB - Defence against bioterrorism: Recent events have created an urgent need for therapeutic strategies to treat anthrax, an infectious disease caused by the toxigenic bacterium Bacillus anthracis. A new class of aminoglycosides (see picture) are powerful inhibitors under physiological conditions of the anthrax lethal factor, which has a major role in the disease, and function simultaneously as antibiotics against B. anthracis. (Chemical Equation Presented).

KW - Aminoglycosides

KW - Anthrax

KW - Antibiotics

KW - Inhibitors

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Dual effect of synthetic aminoglycosides: Antibacterial activity against Bacillus anthracis and inhibition of anthrax lethal factor

Abstract

Keywords

UN SDGs

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