Drugst.One - a plug-and-play solution for online systems medicine and network-based drug repurposing

Andreas Maier; Michael Hartung; Mark Abovsky; Klaudia Adamowicz; Gary D. Bader; Sylvie Baier; David B. Blumenthal; Jing Chen; Maria L. Elkjaer; Carlos Garcia-Hernandez; Mohamed Helmy; Markus Hoffmann; Igor Jurisica; Max Kotlyar; Olga Lazareva; Hagai Levi; Markus List; Sebastian Lobentanzer; Joseph Loscalzo; Noel Malod-Dognin; Quirin Manz; Julian Matschinske; Miles Mee; Mhaned Oubounyt; Chiara Pastrello; Alexander R. Pico; Rudolf T. Pillich; Julian M. Poschenrieder; Dexter Pratt; Nataša Pržulj; Sepideh Sadegh; Julio Saez-Rodriguez; Suryadipto Sarkar; Gideon Shaked; Ron Shamir; Nico Trummer; Ugur Turhan; Rui Sheng Wang; Olga Zolotareva; Jan Baumbach

doi:10.1093/nar/gkae388

Drugst.One - a plug-and-play solution for online systems medicine and network-based drug repurposing

Andreas Maier^*, Michael Hartung, Mark Abovsky, Klaudia Adamowicz, Gary D. Bader, Sylvie Baier, David B. Blumenthal, Jing Chen, Maria L. Elkjaer, Carlos Garcia-Hernandez, Mohamed Helmy, Markus Hoffmann, Igor Jurisica, Max Kotlyar, Olga Lazareva, Hagai Levi, Markus List, Sebastian Lobentanzer, Joseph Loscalzo, Noel Malod-DogninQuirin Manz, Julian Matschinske, Miles Mee, Mhaned Oubounyt, Chiara Pastrello, Alexander R. Pico, Rudolf T. Pillich, Julian M. Poschenrieder, Dexter Pratt, Nataša Pržulj, Sepideh Sadegh, Julio Saez-Rodriguez, Suryadipto Sarkar, Gideon Shaked, Ron Shamir, Nico Trummer, Ugur Turhan, Rui Sheng Wang, Olga Zolotareva, Jan Baumbach

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerged to identify potential drug repurposing candidates. However, these tools often require complex installation and lack intuitive visual network mining capabilities. To tackle these challenges, we introduce Drugst.One, a platform that assists specialized computational medicine tools in becoming user-friendly, web-based utilities for drug repurposing. With just three lines of code, Drugst.One turns any systems biology software into an interactive web tool for modeling and analyzing complex protein-drug-disease networks. Demonstrating its broad adaptability, Drugst.One has been successfully integrated with 21 computational systems medicine tools. Available at https://drugst.one, Drugst.One has significant potential for streamlining the drug discovery process, allowing researchers to focus on essential aspects of pharmaceutical treatment research.

Original language	English
Pages (from-to)	W481-W488
Journal	Nucleic Acids Research
Volume	52
Issue number	W1
DOIs	https://doi.org/10.1093/nar/gkae388
State	Published - 5 Jul 2024

Funding

Funders	Funder number
Technical University Munich Institute for Advanced Study
International Business Machines Corporation
Natural Sciences Research Council
European Union s Horizon 2020 research and innovation programme
Institute for Advanced Study, Technische Universität München
National Institute of Diabetes and Digestive and Kidney Diseases
European Health and Digital Executive Agency
Ian Lawson van Toch Fund
Technische Universität München
German Excellence Initiative
European Union or European Health and Digital Executive Agency
Horizon Europe project Repo4EU
Bundesministerium für Bildung und Forschung	16LW0243K, 161L0214A, F031L0214A
Ontario Research Foundation	RE010-020, RDI #34876
Staatssekretariat für Bildung, Forschung und Innovation	22.00115
Natural Sciences and Engineering Research Council of Canada	203475
European Research Council	770827
Canada Foundation for Innovation	225404, 30865
Horizon 2020 Framework Programme	777111, 965193
Agencia Estatal de Investigación	PID2019-105500GB-I00
Deutsche Forschungsgemeinschaft	13154, 422216132
European Commission	101057619

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10.1093/nar/gkae388

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Maier, A., Hartung, M., Abovsky, M., Adamowicz, K., Bader, G. D., Baier, S., Blumenthal, D. B., Chen, J., Elkjaer, M. L., Garcia-Hernandez, C., Helmy, M., Hoffmann, M., Jurisica, I., Kotlyar, M., Lazareva, O., Levi, H., List, M., Lobentanzer, S., Loscalzo, J., ... Baumbach, J. (2024). Drugst.One - a plug-and-play solution for online systems medicine and network-based drug repurposing. Nucleic Acids Research, 52(W1), W481-W488. https://doi.org/10.1093/nar/gkae388

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abstract = "In recent decades, the development of new drugs has become increasingly expensive and inefficient, and the molecular mechanisms of most pharmaceuticals remain poorly understood. In response, computational systems and network medicine tools have emerged to identify potential drug repurposing candidates. However, these tools often require complex installation and lack intuitive visual network mining capabilities. To tackle these challenges, we introduce Drugst.One, a platform that assists specialized computational medicine tools in becoming user-friendly, web-based utilities for drug repurposing. With just three lines of code, Drugst.One turns any systems biology software into an interactive web tool for modeling and analyzing complex protein-drug-disease networks. Demonstrating its broad adaptability, Drugst.One has been successfully integrated with 21 computational systems medicine tools. Available at https://drugst.one, Drugst.One has significant potential for streamlining the drug discovery process, allowing researchers to focus on essential aspects of pharmaceutical treatment research.",

author = "Andreas Maier and Michael Hartung and Mark Abovsky and Klaudia Adamowicz and Bader, {Gary D.} and Sylvie Baier and Blumenthal, {David B.} and Jing Chen and Elkjaer, {Maria L.} and Carlos Garcia-Hernandez and Mohamed Helmy and Markus Hoffmann and Igor Jurisica and Max Kotlyar and Olga Lazareva and Hagai Levi and Markus List and Sebastian Lobentanzer and Joseph Loscalzo and Noel Malod-Dognin and Quirin Manz and Julian Matschinske and Miles Mee and Mhaned Oubounyt and Chiara Pastrello and Pico, {Alexander R.} and Pillich, {Rudolf T.} and Poschenrieder, {Julian M.} and Dexter Pratt and Nata{\v s}a Pr{\v z}ulj and Sepideh Sadegh and Julio Saez-Rodriguez and Suryadipto Sarkar and Gideon Shaked and Ron Shamir and Nico Trummer and Ugur Turhan and Wang, {Rui Sheng} and Olga Zolotareva and Jan Baumbach",

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Maier, A, Hartung, M, Abovsky, M, Adamowicz, K, Bader, GD, Baier, S, Blumenthal, DB, Chen, J, Elkjaer, ML, Garcia-Hernandez, C, Helmy, M, Hoffmann, M, Jurisica, I, Kotlyar, M, Lazareva, O, Levi, H, List, M, Lobentanzer, S, Loscalzo, J, Malod-Dognin, N, Manz, Q, Matschinske, J, Mee, M, Oubounyt, M, Pastrello, C, Pico, AR, Pillich, RT, Poschenrieder, JM, Pratt, D, Pržulj, N, Sadegh, S, Saez-Rodriguez, J, Sarkar, S, Shaked, G, Shamir, R, Trummer, N, Turhan, U, Wang, RS, Zolotareva, O & Baumbach, J 2024, 'Drugst.One - a plug-and-play solution for online systems medicine and network-based drug repurposing', Nucleic Acids Research, vol. 52, no. W1, pp. W481-W488. https://doi.org/10.1093/nar/gkae388

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T1 - Drugst.One - a plug-and-play solution for online systems medicine and network-based drug repurposing

AU - Maier, Andreas

AU - Hartung, Michael

AU - Abovsky, Mark

AU - Adamowicz, Klaudia

AU - Bader, Gary D.

AU - Baier, Sylvie

AU - Blumenthal, David B.

AU - Chen, Jing

AU - Elkjaer, Maria L.

AU - Garcia-Hernandez, Carlos

AU - Helmy, Mohamed

AU - Hoffmann, Markus

AU - Jurisica, Igor

AU - Kotlyar, Max

AU - Lazareva, Olga

AU - Levi, Hagai

AU - List, Markus

AU - Lobentanzer, Sebastian

AU - Loscalzo, Joseph

AU - Malod-Dognin, Noel

AU - Manz, Quirin

AU - Matschinske, Julian

AU - Mee, Miles

AU - Oubounyt, Mhaned

AU - Pastrello, Chiara

AU - Pico, Alexander R.

AU - Pillich, Rudolf T.

AU - Poschenrieder, Julian M.

AU - Pratt, Dexter

AU - Pržulj, Nataša

AU - Sadegh, Sepideh

AU - Saez-Rodriguez, Julio

AU - Sarkar, Suryadipto

AU - Shaked, Gideon

AU - Shamir, Ron

AU - Trummer, Nico

AU - Turhan, Ugur

AU - Wang, Rui Sheng

AU - Zolotareva, Olga

AU - Baumbach, Jan

PY - 2024/7/5

Y1 - 2024/7/5

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Drugst.One - a plug-and-play solution for online systems medicine and network-based drug repurposing

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