Drug treatment of obsessive-compulsive disorder

Joseph Zohar*, Thomas R. Insel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


Obsessive-compulsive disorder (OCD) traditionally has been considered a rare, treatment refractory disorder of psychological origin. However, OCD appears to be much more common than was previously believed. Moreover, in recent years controlled studies demonstrated that clomipramine is more effective than placebo and than other tricyclics for reducing obsessive-compulsive symptoms. Although it has been suggested that clomipramine was effective in treating obsessive-compulsive symptoms by an antidepressant mechanism, the majority of the controlled studies found that its antiobsessional effects occurred whether the patient was depressed or not. The apparent specificity of clomipramine, and, to some extent, newer serotonin selective antidepressants, suggests a serotonergic role in the psychobiology of OCD.

Original languageEnglish
Pages (from-to)193-202
Number of pages10
JournalJournal of Affective Disorders
Issue number2
StatePublished - 1987
Externally publishedYes


  • Clomipramine
  • Depression
  • Obsessive-compulsive disorder
  • Serotonin selective antidepressant


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