TY - JOUR
T1 - Drug treatment of obsessive-compulsive disorder
AU - Zohar, Joseph
AU - Insel, Thomas R.
PY - 1987
Y1 - 1987
N2 - Obsessive-compulsive disorder (OCD) traditionally has been considered a rare, treatment refractory disorder of psychological origin. However, OCD appears to be much more common than was previously believed. Moreover, in recent years controlled studies demonstrated that clomipramine is more effective than placebo and than other tricyclics for reducing obsessive-compulsive symptoms. Although it has been suggested that clomipramine was effective in treating obsessive-compulsive symptoms by an antidepressant mechanism, the majority of the controlled studies found that its antiobsessional effects occurred whether the patient was depressed or not. The apparent specificity of clomipramine, and, to some extent, newer serotonin selective antidepressants, suggests a serotonergic role in the psychobiology of OCD.
AB - Obsessive-compulsive disorder (OCD) traditionally has been considered a rare, treatment refractory disorder of psychological origin. However, OCD appears to be much more common than was previously believed. Moreover, in recent years controlled studies demonstrated that clomipramine is more effective than placebo and than other tricyclics for reducing obsessive-compulsive symptoms. Although it has been suggested that clomipramine was effective in treating obsessive-compulsive symptoms by an antidepressant mechanism, the majority of the controlled studies found that its antiobsessional effects occurred whether the patient was depressed or not. The apparent specificity of clomipramine, and, to some extent, newer serotonin selective antidepressants, suggests a serotonergic role in the psychobiology of OCD.
KW - Clomipramine
KW - Depression
KW - Obsessive-compulsive disorder
KW - Serotonin selective antidepressant
UR - http://www.scopus.com/inward/record.url?scp=0023233004&partnerID=8YFLogxK
U2 - 10.1016/0165-0327(87)90023-1
DO - 10.1016/0165-0327(87)90023-1
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AN - SCOPUS:0023233004
SN - 0165-0327
VL - 13
SP - 193
EP - 202
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
IS - 2
ER -