Drug rash with eosinophilia and systemic symptoms versus Stevens-Johnson syndrome - A case that indicates a stumbling block in the current classification

Ronni Wolf; Batya Davidovici; Hagit Matz; Keren Mahlab; Edith Orion; Zev M. Sthoeger

doi:10.1159/000095437

Drug rash with eosinophilia and systemic symptoms versus Stevens-Johnson syndrome - A case that indicates a stumbling block in the current classification

Ronni Wolf^*, Batya Davidovici, Hagit Matz, Keren Mahlab, Edith Orion, Zev M. Sthoeger

^*Corresponding author for this work

Clinical Departments

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22 Scopus citations

Abstract

A 43-year-old man developed a skin eruption characterized by 'macules with blisters' typical to Stevens-Johnson syndrome, as well as erosions of the lips and buccal mucosa, 2 weeks after he had started treatment with lamotrigine. He had a fever (39.6°C), elevated liver enzymes and atypical lymphocytes in the peripheral blood. This undoubtedly reflects a case of Stevens-Johnson syndrome induced by lamotrigine, but it can also fulfill the criteria of anticonvulsant hypersensitivity syndrome or drug rash with eosinophilia and systemic signs. A case that precisely fits the definition of two syndromes that have different characteristics, different treatments and different prognoses indicates that there is a flaw in the classification.

Original language	English
Pages (from-to)	308-310
Number of pages	3
Journal	International Archives of Allergy and Immunology
Volume	141
Issue number	3
DOIs	https://doi.org/10.1159/000095437
State	Published - Oct 2006

Keywords

Adverse drug reaction
Drug rash with eosinophilia and systemic signs
Stevens-Johnson syndrome

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10.1159/000095437

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AU - Orion, Edith

AU - Sthoeger, Zev M.

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Drug rash with eosinophilia and systemic symptoms versus Stevens-Johnson syndrome - A case that indicates a stumbling block in the current classification

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Keywords

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