TY - JOUR
T1 - Drug rash with eosinophilia and systemic symptoms versus Stevens-Johnson syndrome - A case that indicates a stumbling block in the current classification
AU - Wolf, Ronni
AU - Davidovici, Batya
AU - Matz, Hagit
AU - Mahlab, Keren
AU - Orion, Edith
AU - Sthoeger, Zev M.
PY - 2006/10
Y1 - 2006/10
N2 - A 43-year-old man developed a skin eruption characterized by 'macules with blisters' typical to Stevens-Johnson syndrome, as well as erosions of the lips and buccal mucosa, 2 weeks after he had started treatment with lamotrigine. He had a fever (39.6°C), elevated liver enzymes and atypical lymphocytes in the peripheral blood. This undoubtedly reflects a case of Stevens-Johnson syndrome induced by lamotrigine, but it can also fulfill the criteria of anticonvulsant hypersensitivity syndrome or drug rash with eosinophilia and systemic signs. A case that precisely fits the definition of two syndromes that have different characteristics, different treatments and different prognoses indicates that there is a flaw in the classification.
AB - A 43-year-old man developed a skin eruption characterized by 'macules with blisters' typical to Stevens-Johnson syndrome, as well as erosions of the lips and buccal mucosa, 2 weeks after he had started treatment with lamotrigine. He had a fever (39.6°C), elevated liver enzymes and atypical lymphocytes in the peripheral blood. This undoubtedly reflects a case of Stevens-Johnson syndrome induced by lamotrigine, but it can also fulfill the criteria of anticonvulsant hypersensitivity syndrome or drug rash with eosinophilia and systemic signs. A case that precisely fits the definition of two syndromes that have different characteristics, different treatments and different prognoses indicates that there is a flaw in the classification.
KW - Adverse drug reaction
KW - Drug rash with eosinophilia and systemic signs
KW - Stevens-Johnson syndrome
UR - http://www.scopus.com/inward/record.url?scp=33750189300&partnerID=8YFLogxK
U2 - 10.1159/000095437
DO - 10.1159/000095437
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C2 - 16940741
AN - SCOPUS:33750189300
SN - 1018-2438
VL - 141
SP - 308
EP - 310
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
IS - 3
ER -