Drug-induced pemphigus

Sarah Brenner*, Ilan Goldberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Pemphigus is an autoimmune bullous disease that may be influenced by genetic and exogenous factors. Drugs are a leading cause of pemphigus. There is a need for a thorough history taking so as to find the culprit medication. The diagnosis of drug-induced pemphigus is challenging. Patients have often been exposed to multiple drugs, and some drugs may have a prolonged latency period between exposure and onset of the disease. The in vitro interferon-gamma (IFN-gamma) release from lymphocytes test has been shown to be of diagnostic value in drug-induced skin reactions. Cessation of the offending drug may alleviate the clinical manifestations and reduce the need for medical treatment.

Original languageEnglish
Pages (from-to)455-457
Number of pages3
JournalClinics in Dermatology
Issue number4
StatePublished - Jul 2011


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