Drug-eluting bioresorbable stents for various applications

Meital Zilberman*, Robert C. Eberhart

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

94 Scopus citations


A stent is a medical device designed to serve as a temporary or permanent internal scaffold to maintain or increase the lumen of a body conduit. Metallic coronary stents were first introduced to prevent arterial dissections and to eliminate vessel recoil and intimal hyperplasia associated with percutaneous transluminal coronary angioplasty. The stent application range has expanded as more experience was gained, and encouraging results have been obtained in the treatment of vascular diseases. Stents are currently used for support of additional body conduits, including the urethra, trachea, and esophagus. The rationale for bioresorbable stents is the support of a body conduit only during its healing process. The stent mass and strength decrease with time, and the mechanical load is gradually transferred to the surrounding tissue. Bioresorbable stents also enable longer term delivery of drugs to the conduit wall from an internal reservoir and abolish the need for a second surgery to remove the device. The present review describes recent advances in bioresorbable stents, focusing on drug-eluting bioresorbable stents for various applications. Controlled release of an active agent from a stent can be used to enhance healing of the surrounding tissues, to increase the implant's biocompatibility, as well as to help cure certain diseases. Because a lot of research in this field has been done by us, examples for these functions are described based mainly on developments in our laboratories.

Original languageEnglish
Title of host publicationAnnual Review of Biomedical Engineering
EditorsMartin Yarmush
PublisherAnnual Reviews Inc.
Number of pages28
ISBN (Print)0824335082, 9780824335083
StatePublished - 2006

Publication series

NameAnnual Review of Biomedical Engineering
ISSN (Print)1523-9829


FundersFunder number
National Heart, Lung, and Blood InstituteR01HL053225
National Heart, Lung, and Blood Institute


    • Bioresorbable polymer
    • Drug delivery
    • Protein delivery
    • Stent


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