Drug delivery to the posterior segment of the eye

Baruch D. Kuppermann, Anat Loewenstein

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Drug delivery into the posterior segment of the eye is complicated by the existence of the blood-ocular barrier. Strategies for delivering drugs to the posterior segment include systemic administration, modification of the barrier, and local drug delivery (including transcorneal, transscleral, and intravitreal). Recently, new topical treatments have emerged for the treatment of posterior eye disease. Iontophoretic, juxtascleral, and intravitreal routes can be used to achieve therapeutic levels in the posterior segment. Extended-release intravitreal drug delivery systems can achieve sustained therapeutic levels with the goal of providing a prolonged clinical benefit.

Original languageEnglish
Title of host publicationMacular Edema
Subtitle of host publicationA Practical Approach
EditorsGabriel Coscas, Gisele Soubrane, Jose Cunha-Vaz, Anat Loewenstein
Pages59-72
Number of pages14
DOIs
StatePublished - 2010

Publication series

NameDevelopments in Ophthalmology
Volume47
ISSN (Print)0250-3751
ISSN (Electronic)1662-2790

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