TY - JOUR
T1 - Drosophila JAB1/CSN5 acts in photoreceptor cells to induce glial cells
AU - Suh, Greg S.B.
AU - Poeck, Burkhard
AU - Chouard, Tanguy
AU - Oron, Efrat
AU - Segal, Daniel
AU - Chamovitz, Daniel A.
AU - Zipursky, S. Lawrence
N1 - Funding Information:
We thank members of the Zipursky lab and Drs. Utpal Banerjee, Eddy De Robertis, and Owen Witte for comments on the manuscript and helpful discussion. G.S. expresses gratitude to Haeri Song for her continuous support, advice, and technical assistance; to Jim Clemens for help on analysis of JAB1/CSN5 structure; and to Linda Ballard for sectioning adult mosaic eyes. This work was supported by the Deutsche Forschungsgemeinschaft (Po 457/3-1) (B.P.), the Human Frontier Science Program LT839/96 (T.C.), and the Israel Science Foundation (D.S. and D.A.C.). S.L.Z. is an investigator of the Howard Hughes Medical Institute.
PY - 2002/1/3
Y1 - 2002/1/3
N2 - Different classes of photoreceptor neurons (R cells) in the Drosophila compound eye form connections in different optic ganglia. The R1-R6 subclass connects to the first optic ganglion, the lamina, and relies upon glial cells as intermediate targets. Conversely, R cells promote glial cell development including migration of glial cells into the target region. Here, we show that the JAB1/CSN5 subunit of the COP9 signalosome complex is expressed in R cells, accumulates in the developing optic lobe neuropil, and through the analysis of a unique set of missense mutations, is required in R cells to induce lamina glial cell migration. In these CSN5 alleles, R1-R6 targeting is disrupted. Genetic analysis of protein null alleles further revealed that the COP9 signalosome is required at an earlier stage of development for R cell differentiation.
AB - Different classes of photoreceptor neurons (R cells) in the Drosophila compound eye form connections in different optic ganglia. The R1-R6 subclass connects to the first optic ganglion, the lamina, and relies upon glial cells as intermediate targets. Conversely, R cells promote glial cell development including migration of glial cells into the target region. Here, we show that the JAB1/CSN5 subunit of the COP9 signalosome complex is expressed in R cells, accumulates in the developing optic lobe neuropil, and through the analysis of a unique set of missense mutations, is required in R cells to induce lamina glial cell migration. In these CSN5 alleles, R1-R6 targeting is disrupted. Genetic analysis of protein null alleles further revealed that the COP9 signalosome is required at an earlier stage of development for R cell differentiation.
UR - https://www.scopus.com/pages/publications/0037012075
U2 - 10.1016/S0896-6273(01)00576-1
DO - 10.1016/S0896-6273(01)00576-1
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AN - SCOPUS:0037012075
SN - 0896-6273
VL - 33
SP - 35
EP - 46
JO - Neuron
JF - Neuron
IS - 1
ER -