Down-regulation of the CD62L antigen as a possible mechanism for neutrophilia during inflammation

Ori Rogowski, Yifaat Sasson, Micha Kassirer, David Zeltser, Nitsan Maharshak, Nadir Arber, Pinchas Halperin, Jacob Serrov, Patrick Sorkin, Amiram Eldor, Shlomo Berliner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The expressions of both the CD11b/CD18 and CD62L (L-selectin) antigens as well as the absolute number of white blood cells in the peripheral circulating pool of blood in 116 patients with various inflammatory conditions were determined. A highly significant (P<0.0001) negative correlation (r=-0.57) was noted between the absolute number of peripheral blood polymorphonuclear leucocytes and the expression of the CD62L antigen on their surface. In view of the role of CD62L antigen in the rolling of leucocytes along endothelial cells in the microvasculature, its down- regulation might explain, at least in part, the demargination and appearance of neutrophilia during inflammation.

Original languageEnglish
Pages (from-to)666-669
Number of pages4
JournalBritish Journal of Haematology
Volume101
Issue number4
DOIs
StatePublished - 1998
Externally publishedYes

Keywords

  • CD11b/CD18
  • CD62L
  • Inflammation
  • L-selectin
  • Leucocyte adhesion molecules

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