Double umbilical cord blood transplant: More than a cell dose?

Anfisa Stanevsky; Avichai Shimoni; Ronit Yerushalmi; Arnon Nagler

doi:10.3109/10428191003699886

Double umbilical cord blood transplant: More than a cell dose?

Anfisa Stanevsky, Avichai Shimoni, Ronit Yerushalmi, Arnon Nagler^*

^*Corresponding author for this work

Hematology

Sheba Medical Center at Tel Hashomer

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Cord blood transplant (CBT) is characterized by the limited amount of hematopoietic stem cells (HSCs), and exhibits higher incidence of engraftment failure. Transplant using two (double) CB units (DCBT) is the most promising strategy to date to augment the total transplanted HSC dose. DCBT increases the availability of transplant to adults, for whom there is only a small chance of finding a matched CB suitable for a single unit transplant. Better selection of CB units, optimization of conditioning regimen, and GVHD prophylaxis are important to further improve DCBT outcomes. In this review we attempt to summarize recent progress in the field of DCBT, to present the strategies applied, and to point out directions for the future.

Original language	English
Pages (from-to)	975-982
Number of pages	8
Journal	Leukemia and Lymphoma
Volume	51
Issue number	6
DOIs	https://doi.org/10.3109/10428191003699886
State	Published - Jun 2010

Keywords

Adults
Cord blood
Double
Expansion
Leukemia
Transplant

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Double umbilical cord blood transplant: More than a cell dose?",

abstract = "Cord blood transplant (CBT) is characterized by the limited amount of hematopoietic stem cells (HSCs), and exhibits higher incidence of engraftment failure. Transplant using two (double) CB units (DCBT) is the most promising strategy to date to augment the total transplanted HSC dose. DCBT increases the availability of transplant to adults, for whom there is only a small chance of finding a matched CB suitable for a single unit transplant. Better selection of CB units, optimization of conditioning regimen, and GVHD prophylaxis are important to further improve DCBT outcomes. In this review we attempt to summarize recent progress in the field of DCBT, to present the strategies applied, and to point out directions for the future.",

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AU - Yerushalmi, Ronit

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Double umbilical cord blood transplant: More than a cell dose?

Abstract

Keywords

UN SDGs

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