Double-phase 99mTc-sestamibi scintimammography and trans-scan in diagnosing breast cancer

Moshe Melloul, Adrian Paz, Gil Ohana, Ora Laver, David Michalevich, Rumelia Koren, Yaakov Wolloch, Gal Rivka

Research output: Contribution to journalArticlepeer-review

Abstract

The goal of our study was to assess the value of both scintimammography with 99mTc-sestamibi (SMM) and trans-scan (T-scan) in detecting breast cancer. Methods: A total of 121 women were evaluated by palpation, mammography, SMM and T-scan. SMM was performed in the prone, breast dependent position. Immediate and delayed views (double-phase) were obtained. T-scan is a new breast imaging method that maps noninvasively the distribution of tissue electrical impedance and capacitance. Results: SMM had 88.9% sensitivity, 88.4% specificity and 88.4% accuracy in detecting breast cancer. SMM had 100% sensitivity in detecting breast tumors >1 cm and only 66% sensitivity in detecting tumors <1 cm. T-scan had 72.2% sensitivity and 67% specificity in detecting breast cancer. It detected one more breast cancer than SMM, at the expense of 27 additional false-positive results. Conclusion: Double-phase SMM was sensitive and specific in detecting breast cancer. This method may reduce the rate of negative breast biopsies in tumors >1 cm. T- scan was only moderately accurate in detecting breast cancer. Its addition to SMM did not improve significantly the rate of breast cancer detection. However, because of its complete noninvasiveness, large-scale applicability and low cost, T-scan deserves further refining.

Original languageEnglish
Pages (from-to)376-380
Number of pages5
JournalJournal of Nuclear Medicine
Volume40
Issue number3
StatePublished - Mar 1999

Keywords

  • Breast cancer
  • Tc-sestamibi scintimammography
  • Trans-scan

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