Double-blind controlled trial of flumazenil in patients who underwent upper gastrointestinal endoscopy

S. Birkenfeld; C. Federico; Y. Dermansky-Avni; R. Bruck; E. Melzer; S. Bar-Meir

doi:10.1016/S0016-5107(89)72902-3

Double-blind controlled trial of flumazenil in patients who underwent upper gastrointestinal endoscopy

S. Birkenfeld, C. Federico, Y. Dermansky-Avni, R. Bruck, E. Melzer, S. Bar-Meir^*

^*Corresponding author for this work

Clinical Departments

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Abstract

The antisedative effect of flumazenil, a benzodiazepine antagonist, was studied in a double-blind placebo controlled trial in 61 patients who underwent upper gastrointestinal endoscopy and sedation with benzodiazepines. The efficacy of flumazenil in reversing the effect of both benzodiazepines, diazepam and midazolam, was significantly higher than placebo (p < 0.0001). The effect of flumazenil was prompt and was clearly noticed at the first assessment, 5 min after its administration. In none of the patients was a relapse of the sedative effect of the benzodiazepines noticed. The administration of flumazenit was free of major side effects. Flumazenil administration permits an earlier discharge of patients following endoscopy. Its availability in the endoscopy suite may improve the outcome of serious but rare side effects related to benzodiazepines.

Original language	English
Pages (from-to)	519-522
Number of pages	4
Journal	Gastrointestinal Endoscopy
Volume	35
Issue number	6
DOIs	https://doi.org/10.1016/S0016-5107(89)72902-3
State	Published - 1989

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abstract = "The antisedative effect of flumazenil, a benzodiazepine antagonist, was studied in a double-blind placebo controlled trial in 61 patients who underwent upper gastrointestinal endoscopy and sedation with benzodiazepines. The efficacy of flumazenil in reversing the effect of both benzodiazepines, diazepam and midazolam, was significantly higher than placebo (p < 0.0001). The effect of flumazenil was prompt and was clearly noticed at the first assessment, 5 min after its administration. In none of the patients was a relapse of the sedative effect of the benzodiazepines noticed. The administration of flumazenit was free of major side effects. Flumazenil administration permits an earlier discharge of patients following endoscopy. Its availability in the endoscopy suite may improve the outcome of serious but rare side effects related to benzodiazepines.",

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AU - Birkenfeld, S.

AU - Federico, C.

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AU - Bruck, R.

AU - Melzer, E.

AU - Bar-Meir, S.

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Double-blind controlled trial of flumazenil in patients who underwent upper gastrointestinal endoscopy

Abstract

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