"dose/duration effect" relationship between alcohol consumption and cerebral atrophy: A psychological and neuroradiological evaluation

Abstract The purpose of this study was to assess the occurrence of brain atrophy in alcoholic patients as measured by two methods-psychological testing and CAT scanning. The study focused upon the relationships between gross cerebral atrophy and two variables which are considered to be major determinants in the development of brain damage. The variables are (1) the quantity-frequency of alcohol intake, and (2) the duration of problematic drinking. The results show that the degree of brain damage is related to the intensity of exposure to alcohol and clearly indicate that psychological testing is a reliable method for, at least, an initial diagnosis of or screening for alcohol-related cerebral atrophy.