Dose-dependent smooth muscle cell proliferation induced by thermal injury with pulsed infrared lasers

Philippe C. Douek, Rosaly Correa, Ellis F. Unger, Richard Neville, Shmuel Banai, Stephen E. Epstein, Martin B. Leon, And Robert F. Bonner

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Pulsed infrared laser irradiation induced localized thermal lesions in arteries by transiently heating to ∼30°C above ambient and subsequent SMC proliferation in rabbits by 3-4 weeks. Neointimal proliferation exhibited a clear dose dependence both as laser fluence was increased (R=0.83) and for a fixed surface irradiation as the depth of the nearest arterial media was decreased (R=0.95). Thermal injury to the arterial wall is shown to be potent stimulus for SMC proliferation, favoring reduction in energies used in laser or thermal angioplasty.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
EditorsJean Louis Coatrieux, Jean Pierre Morucci, Robert Plonsey, Swamy Laxminarayan
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages314-315
Number of pages2
ISBN (Electronic)0780307852
DOIs
StatePublished - 1992
Externally publishedYes
Event14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992 - Paris, France
Duration: 29 Oct 19921 Nov 1992

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume1
ISSN (Print)1557-170X

Conference

Conference14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
Country/TerritoryFrance
CityParis
Period29/10/921/11/92

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