Dose-dependent smooth muscle cell proliferation induced by thermal injury with pulsed infrared lasers

Philippe C. Douek; Rosaly Correa; Ellis F. Unger; Richard Neville; Shmuel Banai; Stephen E. Epstein; Martin B. Leon; And Robert F. Bonner

doi:10.1109/IEMBS.1992.5760981

Dose-dependent smooth muscle cell proliferation induced by thermal injury with pulsed infrared lasers

Philippe C. Douek, Rosaly Correa, Ellis F. Unger, Richard Neville, Shmuel Banai, Stephen E. Epstein, Martin B. Leon, And Robert F. Bonner

National Institutes of Health

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Pulsed infrared laser irradiation induced localized thermal lesions in arteries by transiently heating to ∼30°C above ambient and subsequent SMC proliferation in rabbits by 3-4 weeks. Neointimal proliferation exhibited a clear dose dependence both as laser fluence was increased (R=0.83) and for a fixed surface irradiation as the depth of the nearest arterial media was decreased (R=0.95). Thermal injury to the arterial wall is shown to be potent stimulus for SMC proliferation, favoring reduction in energies used in laser or thermal angioplasty.

Original language	English
Title of host publication	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
Editors	Jean Louis Coatrieux, Jean Pierre Morucci, Robert Plonsey, Swamy Laxminarayan
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	314-315
Number of pages	2
ISBN (Electronic)	0780307852
DOIs	https://doi.org/10.1109/IEMBS.1992.5760981
State	Published - 1992
Externally published	Yes
Event	14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992 - Paris, France Duration: 29 Oct 1992 → 1 Nov 1992

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Volume	1
ISSN (Print)	1557-170X

Conference

Conference	14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
Country/Territory	France
City	Paris
Period	29/10/92 → 1/11/92

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10.1109/IEMBS.1992.5760981

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Douek, P. C., Correa, R., Unger, E. F., Neville, R., Banai, S., Epstein, S. E., Leon, M. B., & Bonner, A. R. F. (1992). Dose-dependent smooth muscle cell proliferation induced by thermal injury with pulsed infrared lasers. In J. L. Coatrieux, J. P. Morucci, R. Plonsey, & S. Laxminarayan (Eds.), Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992 (pp. 314-315). Article 5760981 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 1). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/IEMBS.1992.5760981

Douek, Philippe C. ; Correa, Rosaly ; Unger, Ellis F. et al. / Dose-dependent smooth muscle cell proliferation induced by thermal injury with pulsed infrared lasers. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992. editor / Jean Louis Coatrieux ; Jean Pierre Morucci ; Robert Plonsey ; Swamy Laxminarayan. Institute of Electrical and Electronics Engineers Inc., 1992. pp. 314-315 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "Dose-dependent smooth muscle cell proliferation induced by thermal injury with pulsed infrared lasers",

abstract = "Pulsed infrared laser irradiation induced localized thermal lesions in arteries by transiently heating to ∼30°C above ambient and subsequent SMC proliferation in rabbits by 3-4 weeks. Neointimal proliferation exhibited a clear dose dependence both as laser fluence was increased (R=0.83) and for a fixed surface irradiation as the depth of the nearest arterial media was decreased (R=0.95). Thermal injury to the arterial wall is shown to be potent stimulus for SMC proliferation, favoring reduction in energies used in laser or thermal angioplasty.",

author = "Douek, {Philippe C.} and Rosaly Correa and Unger, {Ellis F.} and Richard Neville and Shmuel Banai and Epstein, {Stephen E.} and Leon, {Martin B.} and Bonner, {And Robert F.}",

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year = "1992",

doi = "10.1109/IEMBS.1992.5760981",

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series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

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Douek, PC, Correa, R, Unger, EF, Neville, R, Banai, S, Epstein, SE, Leon, MB & Bonner, ARF 1992, Dose-dependent smooth muscle cell proliferation induced by thermal injury with pulsed infrared lasers. in JL Coatrieux, JP Morucci, R Plonsey & S Laxminarayan (eds), Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992., 5760981, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 1, Institute of Electrical and Electronics Engineers Inc., pp. 314-315, 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992, Paris, France, 29/10/92. https://doi.org/10.1109/IEMBS.1992.5760981

Dose-dependent smooth muscle cell proliferation induced by thermal injury with pulsed infrared lasers. / Douek, Philippe C.; Correa, Rosaly; Unger, Ellis F. et al.
Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992. ed. / Jean Louis Coatrieux; Jean Pierre Morucci; Robert Plonsey; Swamy Laxminarayan. Institute of Electrical and Electronics Engineers Inc., 1992. p. 314-315 5760981 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Pulsed infrared laser irradiation induced localized thermal lesions in arteries by transiently heating to ∼30°C above ambient and subsequent SMC proliferation in rabbits by 3-4 weeks. Neointimal proliferation exhibited a clear dose dependence both as laser fluence was increased (R=0.83) and for a fixed surface irradiation as the depth of the nearest arterial media was decreased (R=0.95). Thermal injury to the arterial wall is shown to be potent stimulus for SMC proliferation, favoring reduction in energies used in laser or thermal angioplasty.

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Douek PC, Correa R, Unger EF, Neville R, Banai S, Epstein SE et al. Dose-dependent smooth muscle cell proliferation induced by thermal injury with pulsed infrared lasers. In Coatrieux JL, Morucci JP, Plonsey R, Laxminarayan S, editors, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992. Institute of Electrical and Electronics Engineers Inc. 1992. p. 314-315. 5760981. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/IEMBS.1992.5760981

Dose-dependent smooth muscle cell proliferation induced by thermal injury with pulsed infrared lasers

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