TY - GEN
T1 - Dose-dependent smooth muscle cell proliferation induced by thermal injury with pulsed infrared lasers
AU - Douek, Philippe C.
AU - Correa, Rosaly
AU - Unger, Ellis F.
AU - Neville, Richard
AU - Banai, Shmuel
AU - Epstein, Stephen E.
AU - Leon, Martin B.
AU - Bonner, And Robert F.
N1 - Publisher Copyright:
© 1992 IEEE.
PY - 1992
Y1 - 1992
N2 - Pulsed infrared laser irradiation induced localized thermal lesions in arteries by transiently heating to ∼30°C above ambient and subsequent SMC proliferation in rabbits by 3-4 weeks. Neointimal proliferation exhibited a clear dose dependence both as laser fluence was increased (R=0.83) and for a fixed surface irradiation as the depth of the nearest arterial media was decreased (R=0.95). Thermal injury to the arterial wall is shown to be potent stimulus for SMC proliferation, favoring reduction in energies used in laser or thermal angioplasty.
AB - Pulsed infrared laser irradiation induced localized thermal lesions in arteries by transiently heating to ∼30°C above ambient and subsequent SMC proliferation in rabbits by 3-4 weeks. Neointimal proliferation exhibited a clear dose dependence both as laser fluence was increased (R=0.83) and for a fixed surface irradiation as the depth of the nearest arterial media was decreased (R=0.95). Thermal injury to the arterial wall is shown to be potent stimulus for SMC proliferation, favoring reduction in energies used in laser or thermal angioplasty.
UR - http://www.scopus.com/inward/record.url?scp=85067035536&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.1992.5760981
DO - 10.1109/IEMBS.1992.5760981
M3 - ???researchoutput.researchoutputtypes.contributiontobookanthology.conference???
AN - SCOPUS:85067035536
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 314
EP - 315
BT - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
A2 - Coatrieux, Jean Louis
A2 - Morucci, Jean Pierre
A2 - Plonsey, Robert
A2 - Laxminarayan, Swamy
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 1992
Y2 - 29 October 1992 through 1 November 1992
ER -