Dopaminergic dysregulation in schizophrenia: A target for new drugs

Kenneth L. Davis; Michael Fiori; Bonnie M. Davis; Richard C. Mohs; Thomas B. Horvath; Michael Davidson

doi:10.1002/ddr.430090109

Dopaminergic dysregulation in schizophrenia: A target for new drugs

Kenneth L. Davis^*, Michael Fiori, Bonnie M. Davis, Richard C. Mohs, Thomas B. Horvath, Michael Davidson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The dopamine hypothesis postulates that at least some schizophrenic symptoms are a reflection of central nervous system hyperdopaminergia. The evidence for this model is briefly reviewed and its shortcomings highlighted. The dysregulation hypothesis of schizophrenia should be a useful reformulation. Rather than conceptualizing a static hyperdopaminergic state, schizophrenia might be better understood as a reflection of a relative failure of dopaminergic regulation. Evidence for such dysregulation is examined and possible mechanisms are presented. Avenues of future drug research are proposed.

Original language	English
Pages (from-to)	71-83
Number of pages	13
Journal	Drug Development Research
Volume	9
Issue number	1
DOIs	https://doi.org/10.1002/ddr.430090109
State	Published - Sep 1986
Externally published	Yes

Keywords

DA — dopamine
GH — growth hormone
PGE — prostaglandin E
pHVA — plasma homovanillic acid

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10.1002/ddr.430090109

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abstract = "The dopamine hypothesis postulates that at least some schizophrenic symptoms are a reflection of central nervous system hyperdopaminergia. The evidence for this model is briefly reviewed and its shortcomings highlighted. The dysregulation hypothesis of schizophrenia should be a useful reformulation. Rather than conceptualizing a static hyperdopaminergic state, schizophrenia might be better understood as a reflection of a relative failure of dopaminergic regulation. Evidence for such dysregulation is examined and possible mechanisms are presented. Avenues of future drug research are proposed.",

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AU - Mohs, Richard C.

AU - Horvath, Thomas B.

AU - Davidson, Michael

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KW - GH — growth hormone

KW - PGE — prostaglandin E

KW - pHVA — plasma homovanillic acid

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Dopaminergic dysregulation in schizophrenia: A target for new drugs

Abstract

Keywords

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