Dopaminergic drugs influence the intensity of catalepsy induced by microinjections of carbachol into the reticular formation

Zeev Elazar; Donald Ganchrow; Milka Paz; Ruth Rabinowitz; Zvia Paz; Amos D. Korczyn

doi:10.1016/0304-3940(90)90844-Y

Dopaminergic drugs influence the intensity of catalepsy induced by microinjections of carbachol into the reticular formation

Zeev Elazar^*, Donald Ganchrow, Milka Paz, Ruth Rabinowitz, Zvia Paz, Amos D. Korczyn

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Carbachol microinjections into the mesencephalic and pontine reticular formation in rats induced intense and long-lasting catalepsy. Systemically administered haloperidol potentiated, while apomorphine and l-DOPA reduced the cataleptogenic effect of carbachol. These results indicate the existence of functional relations between the cholinergic cataleptogenic mechanism in the reticular formation and the dopaminergic system. They are interpreted in the light of known anatomical ascending and descending interconnections between the reticular formation and basal ganglia.

Original language	English
Pages (from-to)	245-248
Number of pages	4
Journal	Neuroscience Letters
Volume	119
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(90)90844-Y
State	Published - 13 Nov 1990

Keywords

Apomorphine
Carbachol
Catalepsy
Haloperidol
Reticular formation
l-DOPA

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10.1016/0304-3940(90)90844-Y

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title = "Dopaminergic drugs influence the intensity of catalepsy induced by microinjections of carbachol into the reticular formation",

abstract = "Carbachol microinjections into the mesencephalic and pontine reticular formation in rats induced intense and long-lasting catalepsy. Systemically administered haloperidol potentiated, while apomorphine and l-DOPA reduced the cataleptogenic effect of carbachol. These results indicate the existence of functional relations between the cholinergic cataleptogenic mechanism in the reticular formation and the dopaminergic system. They are interpreted in the light of known anatomical ascending and descending interconnections between the reticular formation and basal ganglia.",

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AU - Elazar, Zeev

AU - Ganchrow, Donald

AU - Paz, Milka

AU - Rabinowitz, Ruth

AU - Paz, Zvia

AU - Korczyn, Amos D.

PY - 1990/11/13

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N2 - Carbachol microinjections into the mesencephalic and pontine reticular formation in rats induced intense and long-lasting catalepsy. Systemically administered haloperidol potentiated, while apomorphine and l-DOPA reduced the cataleptogenic effect of carbachol. These results indicate the existence of functional relations between the cholinergic cataleptogenic mechanism in the reticular formation and the dopaminergic system. They are interpreted in the light of known anatomical ascending and descending interconnections between the reticular formation and basal ganglia.

AB - Carbachol microinjections into the mesencephalic and pontine reticular formation in rats induced intense and long-lasting catalepsy. Systemically administered haloperidol potentiated, while apomorphine and l-DOPA reduced the cataleptogenic effect of carbachol. These results indicate the existence of functional relations between the cholinergic cataleptogenic mechanism in the reticular formation and the dopaminergic system. They are interpreted in the light of known anatomical ascending and descending interconnections between the reticular formation and basal ganglia.

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KW - Carbachol

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KW - Haloperidol

KW - Reticular formation

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Dopaminergic drugs influence the intensity of catalepsy induced by microinjections of carbachol into the reticular formation

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Keywords

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