Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease

Doron Merims; Nir Giladi

doi:10.1016/j.parkreldis.2007.09.007

Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease

Doron Merims, Nir Giladi^*

^*Corresponding author for this work

Tel Aviv Sourasky Medical Center

Research output: Contribution to journal › Review article › peer-review

128 Scopus citations

Abstract

Degeneration of the dopaminergic system in Parkinson's disease and longstanding exposure to dopaminergic drugs may cause reward system malfunction. This may manifest as addiction to l-dopa and behavioral disturbances associated with the impulse control system. These disturbances include: gambling, excessive spending (shopping), hypersexuality and binge eating. We included one such patient's personal story to emphasize the devastating consequences of these potentially reversible phenomena: the patient describes in his own words how gambling induced by an exposure dopamine agonist therapy significantly worsened his disease-related difficulties.

Original language	English
Pages (from-to)	273-280
Number of pages	8
Journal	Parkinsonism and Related Disorders
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.parkreldis.2007.09.007
State	Published - May 2008
Externally published	Yes

Keywords

Dopamine agonist
Dopamine dysregulation syndrome
Gambling
Parkinson's disease
l-Dopa

Access to Document

10.1016/j.parkreldis.2007.09.007

Cite this

@article{51c4a44eab9d441db010cb8d61f73a79,

title = "Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease",

abstract = "Degeneration of the dopaminergic system in Parkinson's disease and longstanding exposure to dopaminergic drugs may cause reward system malfunction. This may manifest as addiction to l-dopa and behavioral disturbances associated with the impulse control system. These disturbances include: gambling, excessive spending (shopping), hypersexuality and binge eating. We included one such patient's personal story to emphasize the devastating consequences of these potentially reversible phenomena: the patient describes in his own words how gambling induced by an exposure dopamine agonist therapy significantly worsened his disease-related difficulties.",

keywords = "Dopamine agonist, Dopamine dysregulation syndrome, Gambling, Parkinson's disease, l-Dopa",

author = "Doron Merims and Nir Giladi",

note = "Funding Information: DM was supported in part by an educational grant from the National Parkinson Foundation INC (NPF) USA. This review was written with the support of a center of excellence grant by the National Parkinson Foundation (NPF), Miami, USA. The Authors thank Mrs. Ester Eshkol for editorial support and Mrs. Judith Knaani for secretarial support.",

year = "2008",

month = may,

doi = "10.1016/j.parkreldis.2007.09.007",

language = "אנגלית",

volume = "14",

pages = "273--280",

journal = "Parkinsonism and Related Disorders",

issn = "1353-8020",

publisher = "Elsevier Ltd.",

number = "4",

}

TY - JOUR

T1 - Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease

AU - Merims, Doron

AU - Giladi, Nir

N1 - Funding Information: DM was supported in part by an educational grant from the National Parkinson Foundation INC (NPF) USA. This review was written with the support of a center of excellence grant by the National Parkinson Foundation (NPF), Miami, USA. The Authors thank Mrs. Ester Eshkol for editorial support and Mrs. Judith Knaani for secretarial support.

PY - 2008/5

Y1 - 2008/5

N2 - Degeneration of the dopaminergic system in Parkinson's disease and longstanding exposure to dopaminergic drugs may cause reward system malfunction. This may manifest as addiction to l-dopa and behavioral disturbances associated with the impulse control system. These disturbances include: gambling, excessive spending (shopping), hypersexuality and binge eating. We included one such patient's personal story to emphasize the devastating consequences of these potentially reversible phenomena: the patient describes in his own words how gambling induced by an exposure dopamine agonist therapy significantly worsened his disease-related difficulties.

AB - Degeneration of the dopaminergic system in Parkinson's disease and longstanding exposure to dopaminergic drugs may cause reward system malfunction. This may manifest as addiction to l-dopa and behavioral disturbances associated with the impulse control system. These disturbances include: gambling, excessive spending (shopping), hypersexuality and binge eating. We included one such patient's personal story to emphasize the devastating consequences of these potentially reversible phenomena: the patient describes in his own words how gambling induced by an exposure dopamine agonist therapy significantly worsened his disease-related difficulties.

KW - Dopamine agonist

KW - Dopamine dysregulation syndrome

KW - Gambling

KW - Parkinson's disease

KW - l-Dopa

UR - http://www.scopus.com/inward/record.url?scp=44349131102&partnerID=8YFLogxK

U2 - 10.1016/j.parkreldis.2007.09.007

DO - 10.1016/j.parkreldis.2007.09.007

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???

C2 - 17988927

AN - SCOPUS:44349131102

SN - 1353-8020

VL - 14

SP - 273

EP - 280

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

IS - 4

ER -

Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this