Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease

Doron Merims, Nir Giladi

Research output: Contribution to journalReview articlepeer-review

Abstract

Degeneration of the dopaminergic system in Parkinson's disease and longstanding exposure to dopaminergic drugs may cause reward system malfunction. This may manifest as addiction to l-dopa and behavioral disturbances associated with the impulse control system. These disturbances include: gambling, excessive spending (shopping), hypersexuality and binge eating. We included one such patient's personal story to emphasize the devastating consequences of these potentially reversible phenomena: the patient describes in his own words how gambling induced by an exposure dopamine agonist therapy significantly worsened his disease-related difficulties.

Original languageEnglish
Pages (from-to)273-280
Number of pages8
JournalParkinsonism and Related Disorders
Volume14
Issue number4
DOIs
StatePublished - May 2008
Externally publishedYes

Keywords

  • Dopamine agonist
  • Dopamine dysregulation syndrome
  • Gambling
  • l-Dopa
  • Parkinson's disease

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