Dopamine dysregulation syndrome, addiction and behavioral changes in Parkinson's disease

Doron Merims, Nir Giladi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Degeneration of the dopaminergic system in Parkinson's disease and longstanding exposure to dopaminergic drugs may cause reward system malfunction. This may manifest as addiction to l-dopa and behavioral disturbances associated with the impulse control system. These disturbances include: gambling, excessive spending (shopping), hypersexuality and binge eating. We included one such patient's personal story to emphasize the devastating consequences of these potentially reversible phenomena: the patient describes in his own words how gambling induced by an exposure dopamine agonist therapy significantly worsened his disease-related difficulties.

Original languageEnglish
Pages (from-to)273-280
Number of pages8
JournalParkinsonism and Related Disorders
Issue number4
StatePublished - May 2008
Externally publishedYes


FundersFunder number
National Parkinson Foundation


    • Dopamine agonist
    • Dopamine dysregulation syndrome
    • Gambling
    • Parkinson's disease
    • l-Dopa


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