Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP

Eldad Melamed*, Jutta Rosenthal, Oren Cohen, Globus Mordechai, Anat Uzzan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Combined administration of nomifensine, a DA reuptake inhibitor, and MPTP completely prevented the long-term (30 days post-treatment) striatal DA depletions induced by MPTP in mice. Cotreatment with desipramine and clomipramine or fluoxetine, inhibitors of NE and 5-HT, respectively had no effect on DA neurotoxicity of MPTP. The findings indicate that MPTP (or MPP+) is a substrate for the specific DA reuptake system and may explain, in part, its selective toxic effects on DA neurons.

Original languageEnglish
Pages (from-to)179-181
Number of pages3
JournalEuropean Journal of Pharmacology
Volume116
Issue number1-2
DOIs
StatePublished - 8 Oct 1985
Externally publishedYes

Keywords

  • Clomipramine
  • Desipramine
  • Dopamine
  • Fluoxetine
  • MPTP
  • Nomifensine
  • Norepinephrine
  • Serotonin

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