Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP

Eldad Melamed; Jutta Rosenthal; Oren Cohen; Globus Mordechai; Anat Uzzan

doi:10.1016/0014-2999(85)90201-8

Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP

Eldad Melamed^*, Jutta Rosenthal, Oren Cohen, Globus Mordechai, Anat Uzzan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Combined administration of nomifensine, a DA reuptake inhibitor, and MPTP completely prevented the long-term (30 days post-treatment) striatal DA depletions induced by MPTP in mice. Cotreatment with desipramine and clomipramine or fluoxetine, inhibitors of NE and 5-HT, respectively had no effect on DA neurotoxicity of MPTP. The findings indicate that MPTP (or MPP⁺) is a substrate for the specific DA reuptake system and may explain, in part, its selective toxic effects on DA neurons.

Original language	English
Pages (from-to)	179-181
Number of pages	3
Journal	European Journal of Pharmacology
Volume	116
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-2999(85)90201-8
State	Published - 8 Oct 1985
Externally published	Yes

Keywords

Clomipramine
Desipramine
Dopamine
Fluoxetine
MPTP
Nomifensine
Norepinephrine
Serotonin

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10.1016/0014-2999(85)90201-8

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title = "Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP",

abstract = "Combined administration of nomifensine, a DA reuptake inhibitor, and MPTP completely prevented the long-term (30 days post-treatment) striatal DA depletions induced by MPTP in mice. Cotreatment with desipramine and clomipramine or fluoxetine, inhibitors of NE and 5-HT, respectively had no effect on DA neurotoxicity of MPTP. The findings indicate that MPTP (or MPP+) is a substrate for the specific DA reuptake system and may explain, in part, its selective toxic effects on DA neurons.",

keywords = "Clomipramine, Desipramine, Dopamine, Fluoxetine, MPTP, Nomifensine, Norepinephrine, Serotonin",

author = "Eldad Melamed and Jutta Rosenthal and Oren Cohen and Globus Mordechai and Anat Uzzan",

note = "Funding Information: Supported, in part, by the Lena P. Harvey Endowment Fund for Neurological Research and the Kornfeld Fund for Medical Research.",

year = "1985",

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day = "8",

doi = "10.1016/0014-2999(85)90201-8",

language = "אנגלית",

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pages = "179--181",

journal = "European Journal of Pharmacology",

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TY - JOUR

T1 - Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP

AU - Melamed, Eldad

AU - Rosenthal, Jutta

AU - Cohen, Oren

AU - Mordechai, Globus

AU - Uzzan, Anat

N1 - Funding Information: Supported, in part, by the Lena P. Harvey Endowment Fund for Neurological Research and the Kornfeld Fund for Medical Research.

PY - 1985/10/8

Y1 - 1985/10/8

N2 - Combined administration of nomifensine, a DA reuptake inhibitor, and MPTP completely prevented the long-term (30 days post-treatment) striatal DA depletions induced by MPTP in mice. Cotreatment with desipramine and clomipramine or fluoxetine, inhibitors of NE and 5-HT, respectively had no effect on DA neurotoxicity of MPTP. The findings indicate that MPTP (or MPP+) is a substrate for the specific DA reuptake system and may explain, in part, its selective toxic effects on DA neurons.

AB - Combined administration of nomifensine, a DA reuptake inhibitor, and MPTP completely prevented the long-term (30 days post-treatment) striatal DA depletions induced by MPTP in mice. Cotreatment with desipramine and clomipramine or fluoxetine, inhibitors of NE and 5-HT, respectively had no effect on DA neurotoxicity of MPTP. The findings indicate that MPTP (or MPP+) is a substrate for the specific DA reuptake system and may explain, in part, its selective toxic effects on DA neurons.

KW - Clomipramine

KW - Desipramine

KW - Dopamine

KW - Fluoxetine

KW - MPTP

KW - Nomifensine

KW - Norepinephrine

KW - Serotonin

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U2 - 10.1016/0014-2999(85)90201-8

DO - 10.1016/0014-2999(85)90201-8

M3 - מאמר

AN - SCOPUS:0022388516

VL - 116

SP - 179

EP - 181

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1-2

ER -

Dopamine but not norepinephrine or serotonin uptake inhibitors protect mice against neurotoxicity of MPTP

Abstract

Keywords

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