Donor lymphocyte infusions to displace residual host hematopoietic cells after allogeneic bone marrow transplantation for β-thalassemia major

Memet Aker; Joseph Kapelushnik; Thea Pugatsch; Elizabeth Naparstek; Susana Ben-Neria; Orly Yehuda; Avraham Amar; Arnon Nagler; Shimon Slavin; Reuven Or

doi:10.1097/00043426-199803000-00011

Donor lymphocyte infusions to displace residual host hematopoietic cells after allogeneic bone marrow transplantation for β-thalassemia major

Memet Aker, Joseph Kapelushnik, Thea Pugatsch, Elizabeth Naparstek, Susana Ben-Neria, Orly Yehuda, Avraham Amar, Arnon Nagler, Shimon Slavin^*, Reuven Or

^*Corresponding author for this work

Hadassah University Medical Centre

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Purpose: Donor lymphocyte infusion (DLI) was used to reverse relapse after allogeneic bone marrow transplantation (BMT) in a patient with β- thalassemia major. Patients and Methods: The patient with unstable mixed chimerism after BMT was treated with graded increments of donor lymphocytes (10⁵ T cells/kg to 5x10⁷ T cells/kg) to displace residual hematopoietic host cells. Results: DLI resulted in complete donor-derived reconstitution of the hematopoietic compartment. The patient developed mild graft-versus-host disease (GVHD) that could be controlled by steroid treatment. Conclusions: This case report shows that DLI can effectively eradicate host stem cells in mixed chimeras after BMT in nonmalignant hematopoietic diseases.

Original language	English
Pages (from-to)	145-148
Number of pages	4
Journal	Journal of Pediatric Hematology/Oncology
Volume	20
Issue number	2
DOIs	https://doi.org/10.1097/00043426-199803000-00011
State	Published - Mar 1998
Externally published	Yes

Keywords

Bone marrow transplantation
Donor lymphocyte infusion
β-thalassemia major

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10.1097/00043426-199803000-00011

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Aker, M., Kapelushnik, J., Pugatsch, T., Naparstek, E., Ben-Neria, S., Yehuda, O., Amar, A., Nagler, A., Slavin, S., & Or, R. (1998). Donor lymphocyte infusions to displace residual host hematopoietic cells after allogeneic bone marrow transplantation for β-thalassemia major. Journal of Pediatric Hematology/Oncology, 20(2), 145-148. https://doi.org/10.1097/00043426-199803000-00011

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title = "Donor lymphocyte infusions to displace residual host hematopoietic cells after allogeneic bone marrow transplantation for β-thalassemia major",

abstract = "Purpose: Donor lymphocyte infusion (DLI) was used to reverse relapse after allogeneic bone marrow transplantation (BMT) in a patient with β- thalassemia major. Patients and Methods: The patient with unstable mixed chimerism after BMT was treated with graded increments of donor lymphocytes (105 T cells/kg to 5x107 T cells/kg) to displace residual hematopoietic host cells. Results: DLI resulted in complete donor-derived reconstitution of the hematopoietic compartment. The patient developed mild graft-versus-host disease (GVHD) that could be controlled by steroid treatment. Conclusions: This case report shows that DLI can effectively eradicate host stem cells in mixed chimeras after BMT in nonmalignant hematopoietic diseases.",

keywords = "Bone marrow transplantation, Donor lymphocyte infusion, β-thalassemia major",

author = "Memet Aker and Joseph Kapelushnik and Thea Pugatsch and Elizabeth Naparstek and Susana Ben-Neria and Orly Yehuda and Avraham Amar and Arnon Nagler and Shimon Slavin and Reuven Or",

year = "1998",

month = mar,

doi = "10.1097/00043426-199803000-00011",

language = "אנגלית",

volume = "20",

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journal = "Journal of Pediatric Hematology/Oncology",

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Aker, M, Kapelushnik, J, Pugatsch, T, Naparstek, E, Ben-Neria, S, Yehuda, O, Amar, A, Nagler, A, Slavin, S & Or, R 1998, 'Donor lymphocyte infusions to displace residual host hematopoietic cells after allogeneic bone marrow transplantation for β-thalassemia major', Journal of Pediatric Hematology/Oncology, vol. 20, no. 2, pp. 145-148. https://doi.org/10.1097/00043426-199803000-00011

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T1 - Donor lymphocyte infusions to displace residual host hematopoietic cells after allogeneic bone marrow transplantation for β-thalassemia major

AU - Aker, Memet

AU - Kapelushnik, Joseph

AU - Pugatsch, Thea

AU - Naparstek, Elizabeth

AU - Ben-Neria, Susana

AU - Yehuda, Orly

AU - Amar, Avraham

AU - Nagler, Arnon

AU - Slavin, Shimon

AU - Or, Reuven

PY - 1998/3

Y1 - 1998/3

N2 - Purpose: Donor lymphocyte infusion (DLI) was used to reverse relapse after allogeneic bone marrow transplantation (BMT) in a patient with β- thalassemia major. Patients and Methods: The patient with unstable mixed chimerism after BMT was treated with graded increments of donor lymphocytes (105 T cells/kg to 5x107 T cells/kg) to displace residual hematopoietic host cells. Results: DLI resulted in complete donor-derived reconstitution of the hematopoietic compartment. The patient developed mild graft-versus-host disease (GVHD) that could be controlled by steroid treatment. Conclusions: This case report shows that DLI can effectively eradicate host stem cells in mixed chimeras after BMT in nonmalignant hematopoietic diseases.

AB - Purpose: Donor lymphocyte infusion (DLI) was used to reverse relapse after allogeneic bone marrow transplantation (BMT) in a patient with β- thalassemia major. Patients and Methods: The patient with unstable mixed chimerism after BMT was treated with graded increments of donor lymphocytes (105 T cells/kg to 5x107 T cells/kg) to displace residual hematopoietic host cells. Results: DLI resulted in complete donor-derived reconstitution of the hematopoietic compartment. The patient developed mild graft-versus-host disease (GVHD) that could be controlled by steroid treatment. Conclusions: This case report shows that DLI can effectively eradicate host stem cells in mixed chimeras after BMT in nonmalignant hematopoietic diseases.

KW - Bone marrow transplantation

KW - Donor lymphocyte infusion

KW - β-thalassemia major

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Donor lymphocyte infusions to displace residual host hematopoietic cells after allogeneic bone marrow transplantation for β-thalassemia major

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