Donor lymphocyte infusions to displace residual host hematopoietic cells after allogeneic bone marrow transplantation for β-thalassemia major

Memet Aker, Joseph Kapelushnik, Thea Pugatsch, Elizabeth Naparstek, Susana Ben-Neria, Orly Yehuda, Avraham Amar, Arnon Nagler, Shimon Slavin*, Reuven Or

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Donor lymphocyte infusion (DLI) was used to reverse relapse after allogeneic bone marrow transplantation (BMT) in a patient with β- thalassemia major. Patients and Methods: The patient with unstable mixed chimerism after BMT was treated with graded increments of donor lymphocytes (105 T cells/kg to 5x107 T cells/kg) to displace residual hematopoietic host cells. Results: DLI resulted in complete donor-derived reconstitution of the hematopoietic compartment. The patient developed mild graft-versus-host disease (GVHD) that could be controlled by steroid treatment. Conclusions: This case report shows that DLI can effectively eradicate host stem cells in mixed chimeras after BMT in nonmalignant hematopoietic diseases.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Volume20
Issue number2
DOIs
StatePublished - Mar 1998
Externally publishedYes

Keywords

  • Bone marrow transplantation
  • Donor lymphocyte infusion
  • β-thalassemia major

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