Dominant inheritance in two families with Familial Mediterranean Fever (FMF)

Y. Yuval, M. Hemo-Zisser, D. Zemer, E. Sohar, M. Pras*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Familial Mediterranean fever (FMF) is an autosomal-recessive disease which affects almost exclusively people of Mediterranean and Middle Eastern origin. We examined the possibility of a dominant inheritance of FMF among our 3,000 patients in Israel. Two hundred forty FMF patients were members of 77 families in which the disease affected more than one generation. In 75 of these families the occurrence of FMF in more than one generation was found to be consistent with a recessive mode of inheritance due to a high gene frequency (q) and consanguinity among parents of the patients. In 2 families, one of Ashkenazi and the other of Georgian Iraqi origin, in which FMF occurred in 4 consecutive generations, the mode of inheritance could be explained only by autosomal-dominant inheritance.

Original languageEnglish
Pages (from-to)455-457
Number of pages3
JournalAmerican Journal of Medical Genetics
Issue number3
StatePublished - 1995
Externally publishedYes


  • dominant inheritance
  • familial Mediterranean fever


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