Does SCFD1 rs10139154 Polymorphism Decrease Alzheimer’s Disease Risk?

Polyxeni Stamati, Vasileios Siokas, Athina Maria Aloizou, Emmanouil Karampinis, Stylianos Arseniou, Valerii N. Rakitskii, Aristidis Tsatsakis, Demetrios A. Spandidos, Illana Gozes, Panayiotis D. Mitsias, Dimitrios P. Bogdanos, Georgios M. Hadjigeorgiou, Efthimios Dardiotis

Research output: Contribution to journalArticlepeer-review

Abstract

Α number of genetic variants have been associated with Alzheimer’s disease (AD) susceptibility. Sec1 family domain-containing protein 1 (SCFD1) gene polymorphism rs10139154 has recently been implicated in the risk of developing amyotrophic lateral sclerosis (ALS). Similarities in the pathogenetic cascade of both diseases have also been described. The present study was designed to evaluate the possible contribution of SCFD1 rs10139154 to AD. A total of 327 patients with AD and an equal number of healthy controls were included in the study and genotyped for rs10139154. With logistic regression analyses, rs10139154 was examined for the association with the risk of developing AD. In the recessive mode, SCFD1 rs10139154 was associated with a decreased risk of developing AD (odds ratio (OR) (95% confidence interval (CI)) = 0.63 (0.40–0.97), p = 0.036). The current study provides preliminary evidence of the involvement of SCFD1 rs10139154 in the risk of developing AD.

Original languageEnglish
Pages (from-to)343-350
Number of pages8
JournalJournal of Molecular Neuroscience
Volume69
Issue number2
DOIs
StatePublished - 1 Oct 2019

Keywords

  • AD
  • Genetics
  • Polymorphism
  • SCFD1
  • SNPs

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