Does mRNA SARS-CoV-2 vaccine influence patients' performance during IVF-ET cycle?

Raoul Orvieto*, Meirav Noach-Hirsh, Aliza Segev-Zahav, Jigal Haas, Ravit Nahum, Adva Aizer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: No information exists in the literature regarding the effect of mRNA SARS-CoV-2 vaccine on subsequent IVF cycle attempt. We therefore aim to assess the influence of mRNA SARS-CoV-2 vaccine on IVF treatments. Design: An observational study. Setting: A tertiary, university-affiliated medical center. Patients and Methods: All couples undergoing consecutive ovarian stimulation cycles for IVF before and after receiving mRNA SARS-CoV-2 vaccine, and reached the ovum pick-up (OPU) stage. The stimulation characteristics and embryological variables of couples undergoing IVF treatments after receiving mRNA SARS-CoV-2 vaccine were assessed and compared to their IVF cycles prior to vaccination. Main outcome measures: Stimulation characteristics and embryological variables. Results: Thirty-six couples resumed IVF treatment 7–85 days after receiving mRNA SARS-CoV-2 vaccine. No in-between cycles differences were observed in ovarian stimulation and embryological variables before and after receiving mRNA SARS-CoV-2 vaccination. Conclusions: mRNA SARS-CoV-2 vaccine did not affect patients’ performance or ovarian reserve in their immediate subsequent IVF cycle. Future larger studies with longer follow-up will be needed to validate our observations.

Original languageEnglish
Article number69
JournalReproductive Biology and Endocrinology
Issue number1
StatePublished - Dec 2021


  • COVID-19
  • IVF
  • Ovarian stimulation
  • embryo quality
  • vaccination


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