TY - JOUR
T1 - Does donor-recipient age difference matter in outcome of heart transplantation?
AU - Ram, Eilon
AU - Lavee, Jacob
AU - Kogan, Alexander
AU - Kassif, Yigal
AU - Elian, Dan
AU - Freimark, Dov
AU - Peled, Yael
N1 - Publisher Copyright:
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2019/7
Y1 - 2019/7
N2 - Objective: Potential interactions between donor-recipient age difference and outcomes after heart transplantation are not well known. We thus aimed to study the impact of donor-recipient age difference on heart transplantation outcomes. Methods: Between 1995 and 2017, we assessed 234 heart transplantation patients. Based on donor-recipient age difference histogram, we stratified these patients into three groups: older donors (donor-recipient difference > 0; n = 48), younger donors (donor-recipient difference 0 to −20 years; n = 82), and much younger donors (donor-recipient difference <−20 years; n = 104). Results: The baseline metabolic risk profile of the recipients was significantly higher for the much younger donor group compared with the younger and older groups, including hypertension (52% vs 33% vs 25%, P = 0.002), dyslipidemia (51% vs 51% vs 29%, P = 0.027), diabetes (30% vs 16% vs 17%, P = 0.044), and smoking history (53% vs 46% vs 29%, P = 0.024), respectively. There were no significant differences between the groups in long-term survival, cardiac allograft vasculopathy, or rejection-free survival in unadjusted and adjusted analyses. In the much younger donor group, gender matching was associated with a lower incidence of primary graft dysfunction (37% vs 58% P = 0.05). Conclusions: Donor-recipient age difference does not significantly impact long-term heart transplantation outcomes.
AB - Objective: Potential interactions between donor-recipient age difference and outcomes after heart transplantation are not well known. We thus aimed to study the impact of donor-recipient age difference on heart transplantation outcomes. Methods: Between 1995 and 2017, we assessed 234 heart transplantation patients. Based on donor-recipient age difference histogram, we stratified these patients into three groups: older donors (donor-recipient difference > 0; n = 48), younger donors (donor-recipient difference 0 to −20 years; n = 82), and much younger donors (donor-recipient difference <−20 years; n = 104). Results: The baseline metabolic risk profile of the recipients was significantly higher for the much younger donor group compared with the younger and older groups, including hypertension (52% vs 33% vs 25%, P = 0.002), dyslipidemia (51% vs 51% vs 29%, P = 0.027), diabetes (30% vs 16% vs 17%, P = 0.044), and smoking history (53% vs 46% vs 29%, P = 0.024), respectively. There were no significant differences between the groups in long-term survival, cardiac allograft vasculopathy, or rejection-free survival in unadjusted and adjusted analyses. In the much younger donor group, gender matching was associated with a lower incidence of primary graft dysfunction (37% vs 58% P = 0.05). Conclusions: Donor-recipient age difference does not significantly impact long-term heart transplantation outcomes.
KW - age
KW - donor
KW - heart transplantation
KW - recipient
UR - http://www.scopus.com/inward/record.url?scp=85067667418&partnerID=8YFLogxK
U2 - 10.1111/ctr.13593
DO - 10.1111/ctr.13593
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C2 - 31148258
AN - SCOPUS:85067667418
SN - 0902-0063
VL - 33
JO - Clinical Transplantation
JF - Clinical Transplantation
IS - 7
M1 - e13593
ER -