Do soluble cell adhesion molecules play a role in endometriosis?

Yair Daniel, Amiram Baram, Gideon Fait, Joseph B. Lessing, Eli Geva, Ami Amit, Talma Eshed-Englender

Research output: Contribution to journalArticlepeer-review


PROBLEM: Endometriosis is a chronic inflammatory disease associated with diverse immunologic disturbances. Cell adhesion molecules are essential for the development of immune and inflammatory reactions. This study was conducted to investigate whether or not serum and peritoneal levels of soluble cell adhesion molecules are altered in women with endometriosis. METHOD OF STUDY: The study group comprised five women with moderate-to-severe endometriosis. Eight healthy women with a normal diagnostic laparoscopy served as controls. Serum and peritoneal fluid samples from both groups were analyzed for the soluble isoform of intercellular cell adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1). endothelial selectin (sES), and platelet selectin (sPS). RESULTS: Serum levels of sICAM-1 were significantly increased in women with endometriosis (median levels: 410.4 ng/mL; range: 233.9 ng/mL-598.4 ng/mL vs. 235.7 ng/mL; range: 187.4 ng/mL-323.7 ng/mL; P = 0.02). Although the levels of sVCAM-1, sES, and sPS in both samples were higher in the study group, the differences did not reach significance. CONCLUSIONS: Our results suggest a role of ICAM-1 in the pathophysiology of endometriosis. However, the role of other investigated cell adhesion molecules should be confirmed by further studies.

Original languageEnglish
Pages (from-to)160-166
Number of pages7
JournalAmerican Journal of Reproductive Immunology
Issue number3
StatePublished - Mar 2000
Externally publishedYes


  • Endometriosis
  • Endothelial selectin
  • ICAM-1
  • Inflammation
  • Platelet selectin
  • Soluble cell adhesion molecules
  • VCAM-1


Dive into the research topics of 'Do soluble cell adhesion molecules play a role in endometriosis?'. Together they form a unique fingerprint.

Cite this