Do Follicles of Obese Patients Yield Competent Oocytes/Embryos?

Raoul Orvieto*, Aya Mohr-Sasson, Adva Aizer, Ravit Nahum, Shlomit Blumenfeld, Michal Kirshenbaum, Jigal Haas

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Aim: This study evaluated the competency of oocytes/embryos derived from follicles >15 mm in diameter from obese patients, compared with nonobese patients. Patients and Methods: A cohort study was conducted in a single tertiary medical center between July 2018 and May 2019. Before ultrasound-guided follicular aspiration, follicles were measured and those with maximal dimensional size >15 mm were tracked. Microscopic examination of the follicular aspirates was performed by an embryologist. Each follicle aspirated was evaluated for oocyte maturation, oocyte fertilization, and embryo quality. Results: 457 follicles were measured: 380 (83.2%) in nonobese and 77 (16.8%) in obese patients. No in-between group differences were observed in the causes of infertility, patients' demographics, or ovarian stimulation characteristics. Oocytes were achieved during aspiration from 277 (72.8%) and 54 (70.0%) of the nonobese and obese groups, respectively (p = 0.67). No in-between group differences were observed in fertilization (2PN/oocyte), top quality embryo (TQE) per zygote (2PN), and TQE per follicle. Conclusion: Oocyte recovery rate from follicles >15 mm is unrelated to patients' BMI. Moreover, the oocytes recovered from obese patients are competent yielding comparable zygote and TQE per follicle/oocyte, compared with nonobese patients. Further investigation is required to strengthen this finding.

Original languageEnglish
Pages (from-to)290-293
Number of pages4
JournalGynecologic and Obstetric Investigation
Issue number3
StatePublished - 1 Jun 2020


  • Body mass index
  • Follicle size
  • In vitro fertilization
  • Obesity
  • Oocyte maturation
  • Top quality embryo


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