TY - JOUR
T1 - Do endogenous cannabinoids contribute to HIV-mediated immune failure?
AU - Gurwitz, David
AU - Kloog, Yoel
N1 - Funding Information:
For the loan of specimens, I am indebted to: Mr M. D. Webb (BMNH), Dr. Zaidi Moh. Isa (UKM), Dr H. J. Zainal Abidin B. Jamaluddin (MNKM), Dr M. Gogala and Dr T. Trilar (PMS), Mr J. van Tol (RMNH) and Mrs T. Kothe (ZSM). I am very grateful to Dick Langerak for preparing the figures, to Rob Portegies for making the maps of distribution, and to Gerard Verlaan for technical assistance. The help received from Dr. Maryati Mohamed, head of the Institute for Tropical Biology and Conservation, Universiti Malaysia Sabah, has greatly facilitated our fieldwork in Sabah in 2001; the very kind assistance received from the staff of the institute, and especially from Nordin Wahid and Zainac Awank during the fieldwork, is gratefully acknowledged. My wife Greet Duffels-van Egmond provided again invaluable help during the fieldwork. The fieldtrips in Sabah were financially supported by the Uyttenboogaart-Eliasen Foundation, Amsterdam and the Universiti Malaysia Sabah.
PY - 1998/5/1
Y1 - 1998/5/1
N2 - The failure of the immune system to mount a successful attack on the human immunodeficiency virus (HIV) is an old enigma for AIDS research. The high mutational capacity of HIV, which unremittingly confuses the immune system, is a major factor in immune failure. But this alone cannot fully explain the certain and inescapable failure of the immune system, leading to full-blown AIDS. Here, we propose the hypothesis that endogenous cannabinoids, derived mostly from macrophages, might participate in the general failure of the immune system in HIV-infected individuals.
AB - The failure of the immune system to mount a successful attack on the human immunodeficiency virus (HIV) is an old enigma for AIDS research. The high mutational capacity of HIV, which unremittingly confuses the immune system, is a major factor in immune failure. But this alone cannot fully explain the certain and inescapable failure of the immune system, leading to full-blown AIDS. Here, we propose the hypothesis that endogenous cannabinoids, derived mostly from macrophages, might participate in the general failure of the immune system in HIV-infected individuals.
UR - http://www.scopus.com/inward/record.url?scp=0031803318&partnerID=8YFLogxK
U2 - 10.1016/S1357-4310(98)01254-4
DO - 10.1016/S1357-4310(98)01254-4
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AN - SCOPUS:0031803318
SN - 1357-4310
VL - 4
SP - 196
EP - 200
JO - Molecular Medicine Today
JF - Molecular Medicine Today
IS - 5
ER -
