DNA origami based Au-Ag-core-shell nanoparticle dimers with single-molecule SERS sensitivity

J. Prinz; C. Heck; L. Ellerik; V. Merk; I. Bald

doi:10.1039/c5nr08674d

DNA origami based Au-Ag-core-shell nanoparticle dimers with single-molecule SERS sensitivity

J. Prinz, C. Heck, L. Ellerik, V. Merk, I. Bald^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

DNA origami nanostructures are a versatile tool to arrange metal nanostructures and other chemical entities with nanometer precision. In this way gold nanoparticle dimers with defined distance can be constructed, which can be exploited as novel substrates for surface enhanced Raman scattering (SERS). We have optimized the size, composition and arrangement of Au/Ag nanoparticles to create intense SERS hot spots, with Raman enhancement up to 10¹⁰, which is sufficient to detect single molecules by Raman scattering. This is demonstrated using single dye molecules (TAMRA and Cy3) placed into the center of the nanoparticle dimers. In conjunction with the DNA origami nanostructures novel SERS substrates are created, which can in the future be applied to the SERS analysis of more complex biomolecular targets, whose position and conformation within the SERS hot spot can be precisely controlled.

Original language	English
Pages (from-to)	5612-5620
Number of pages	9
Journal	Nanoscale
Volume	8
Issue number	10
DOIs	https://doi.org/10.1039/c5nr08674d
State	Published - 14 Mar 2016
Externally published	Yes

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abstract = "DNA origami nanostructures are a versatile tool to arrange metal nanostructures and other chemical entities with nanometer precision. In this way gold nanoparticle dimers with defined distance can be constructed, which can be exploited as novel substrates for surface enhanced Raman scattering (SERS). We have optimized the size, composition and arrangement of Au/Ag nanoparticles to create intense SERS hot spots, with Raman enhancement up to 1010, which is sufficient to detect single molecules by Raman scattering. This is demonstrated using single dye molecules (TAMRA and Cy3) placed into the center of the nanoparticle dimers. In conjunction with the DNA origami nanostructures novel SERS substrates are created, which can in the future be applied to the SERS analysis of more complex biomolecular targets, whose position and conformation within the SERS hot spot can be precisely controlled.",

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AU - Merk, V.

AU - Bald, I.

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DNA origami based Au-Ag-core-shell nanoparticle dimers with single-molecule SERS sensitivity

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