@article{5d9ffda2846a4ed6b102d6e87a6ed7a6,
title = "DNA machines: Bipedal walker and stepper",
abstract = "The assembly of a {"}bipedal walker{"} and of a {"}bipedal stepper{"} using DNA constructs is described. These DNA machines are activated by H+/OH- and Hg2+/cysteine triggers. The bipedal walker is activated on a DNA template consisting of four nucleic acid footholds. The forward {"}walking{"} of the DNA on the template track is activated by Hg2+ ions and H+ ions, respectively, using the thymine-Hg2+-thymine complex or the i-motif structure as the DNA translocation driving forces. The backward {"}walking{"} is activated by OH- ions and cysteine, triggers that destroy the i-motif or thymine-Hg2+-thymine complexes. Similarly, the {"}bipedal stepper{"} is activated on a circular DNA template consisting of four tethered footholds. With the Hg2+/cysteine and H+/OH - triggers, clockwise or anticlockwise stepping is demonstrated. The operation of the DNA machines is followed optically by the appropriate labeling of the walker-foothold components with the respective fluorophores/quenchers units.",
keywords = "I-motif, Ions, Machines, Molecular devices, Nucleic acid, pH",
author = "Wang, {Zhen Gang} and Johann Elbaz and Itamar Willner",
year = "2011",
month = jan,
day = "12",
doi = "10.1021/nl104088s",
language = "אנגלית",
volume = "11",
pages = "304--309",
journal = "Nano Letters",
issn = "1530-6984",
publisher = "American Chemical Society",
number = "1",
}