Abstract
DNA likes corroles and peroxynitrite doesn't: The water-soluble manganese corrole (crystal structure shown) is a much better catalyst than the analogous porphyrin for decomposition of peroxynitrite (HOONO). The interactions of the two complexes with DNA are also significantly different. These findings suggest that positively charged corroles may be useful for therapeutic approaches. (Figure Presented)
Original language | English |
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Pages (from-to) | 4320-4324 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 46 |
Issue number | 23 |
DOIs | |
State | Published - 24 Mar 2007 |
Keywords
- Corroles
- DNA
- Manganese
- Peroxynitrite
- Porphyrinoids
- Structure elucidation