DMSO-mediated ligand dissociation: Renaissance for biological activity of N-heterocyclic-[Ru(η6-arene)Cl2] drug candidates

Malay Patra; Tanmaya Joshi; Vanessa Pierroz; Katrin Ingram; Marcel Kaiser; Stefano Ferrari; Bernhard Spingler; Jennifer Keiser; Gilles Gasser

doi:10.1002/chem.201303341

DMSO-mediated ligand dissociation: Renaissance for biological activity of N-heterocyclic-[Ru(η⁶-arene)Cl₂] drug candidates

Malay Patra^*, Tanmaya Joshi, Vanessa Pierroz, Katrin Ingram, Marcel Kaiser, Stefano Ferrari, Bernhard Spingler, Jennifer Keiser, Gilles Gasser

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Slipped under the radar? ¹HNMR spectroscopic examination revealed that [Ru(η⁶-arene)Cl₂(L)] (L=N-heterocyclic ligands) complexes readily undergo a ligand exchange reaction in DMSO (see scheme), a popular medium for preparing stock solutions for biological screening. It is therefore highly important for researchers to study the stability in DMSO before reporting on the biological activity of such complexes.

Original language	English
Pages (from-to)	14768-14772
Number of pages	5
Journal	Chemistry - A European Journal
Volume	19
Issue number	44
DOIs	https://doi.org/10.1002/chem.201303341
State	Published - 25 Oct 2013
Externally published	Yes

Keywords

N-heterocycles
bioorganometallic chemistry
dimethyl sulfoxide
ligand exchange
ruthenium

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10.1002/chem.201303341

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abstract = "Slipped under the radar? 1HNMR spectroscopic examination revealed that [Ru(η6-arene)Cl2(L)] (L=N-heterocyclic ligands) complexes readily undergo a ligand exchange reaction in DMSO (see scheme), a popular medium for preparing stock solutions for biological screening. It is therefore highly important for researchers to study the stability in DMSO before reporting on the biological activity of such complexes.",

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AU - Pierroz, Vanessa

AU - Ingram, Katrin

AU - Kaiser, Marcel

AU - Ferrari, Stefano

AU - Spingler, Bernhard

AU - Keiser, Jennifer

AU - Gasser, Gilles

PY - 2013/10/25

Y1 - 2013/10/25

N2 - Slipped under the radar? 1HNMR spectroscopic examination revealed that [Ru(η6-arene)Cl2(L)] (L=N-heterocyclic ligands) complexes readily undergo a ligand exchange reaction in DMSO (see scheme), a popular medium for preparing stock solutions for biological screening. It is therefore highly important for researchers to study the stability in DMSO before reporting on the biological activity of such complexes.

AB - Slipped under the radar? 1HNMR spectroscopic examination revealed that [Ru(η6-arene)Cl2(L)] (L=N-heterocyclic ligands) complexes readily undergo a ligand exchange reaction in DMSO (see scheme), a popular medium for preparing stock solutions for biological screening. It is therefore highly important for researchers to study the stability in DMSO before reporting on the biological activity of such complexes.

KW - N-heterocycles

KW - bioorganometallic chemistry

KW - dimethyl sulfoxide

KW - ligand exchange

KW - ruthenium

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DMSO-mediated ligand dissociation: Renaissance for biological activity of N-heterocyclic-[Ru(η⁶-arene)Cl₂] drug candidates

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