Diversity of rotavirus strains circulating in Haiti before and after introduction of monovalent vaccine

Mentor Ali Ber Lucien*, Mathew D. Esona, Manise Pierre, Gerard Joseph, Chedelène Rivière, Eyal Leshem, Negar Aliabadi, Anne Marie Desormeaux, Jocelyn Andre-Alboth, David L. Fitter, Yoran Grant-Greene, Jacqueline Tate, Jacques Boncy, Roopal Patel, Eleanor Burnett, Stanley Juin, Umesh D. Parashar, Michael D. Bowen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Haiti introduced a monovalent human group A rotavirus (RVA) vaccine (Rotarix) into its routine infant immunization program in April 2014. The goal of the surveillance program was to characterize RVA strains circulating in Haiti before and after RVA vaccine introduction. Methods: Stool samples were collected from children <5 years old presenting with acute gastroenteritis at 16 hospitals in Haiti. RVA antigen enzyme immunoassay (EIA) testing was performed, and G and P genotypes were determined for positive specimens. In this study, genotype data for samples collected from May 2012 through April 2014 (the pre-vaccine introduction era) and May 2014 through July 2019 (post-vaccine introduction era) were analyzed. Results: A total of 809 specimens were tested by the Centers for Disease Control and Prevention. During the pre-vaccine introduction era (May 2012 through April 2014), G12P[8] was the predominant genotype, detected in 88–94% of specimens. There was a high prevalence of the equine-like G3P[8] genotype among Haitian children with RVA after vaccine introduction. Conclusions: The predominance of equine-like G3P[8] in three of five RVA seasons post-vaccine introduction suggests possible vaccine-specific selection pressure in Haiti. These temporal variations in RVA genotype predominance will require continued monitoring in Haiti as the vaccination program continues.

Original languageEnglish
Pages (from-to)146-151
Number of pages6
JournalIJID Regions
Volume4
DOIs
StatePublished - Sep 2022
Externally publishedYes

Keywords

  • Haiti
  • Pre- and post-vaccination
  • RT-PCR
  • Rotavirus genotypes

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