Diverse niches within multiple myeloma bone marrow aspirates affect plasma cell enumeration

Liat Nadav, Ben Zion Katz, Shoshana Baron, Lydia Yossipov, Aaron Polliack, Varda Deutsch, Benjamin Geiger, Ellizabeth Naparstek

Research output: Contribution to journalArticlepeer-review

Abstract

A basic criterion for the diagnosis of multiple myeloma is plasma cell enumeration within the bone marrow (BM). This report showed that flow cytometry under-estimated the number of plasma cells in BM aspirates by an average of 60%, compared with morphological evaluation. The discrepancy was partially because BM smears contain cells associated with the lipid-enriched spicules. In contrast, flow cytometry is performed on the BM fluid, which is depleted of the lipid-adhesive plasma cells. This discrepancy may point to different plasma cell subpopulations associated with diverse niches within the BM.

Original languageEnglish
Pages (from-to)530-532
Number of pages3
JournalBritish Journal of Haematology
Volume133
Issue number5
DOIs
StatePublished - Jun 2006

Keywords

  • Bone marrow
  • Flow cytometry
  • Multiple myeloma
  • Plasma cells

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