Diurnal glycemic profile in obese and normal weight nondiabetic pregnant women

Yariv Yogev, Avi Ben-Haroush, Rony Chen, Barak Rosenn, Moshe Hod, Oded Langer

Research output: Contribution to journalArticlepeer-review

Abstract

A paucity of data exists concerning the normal glycemic profile in nondiabetic pregnancies. Using a novel approach that provides continuous measurement of blood glucose, we sought to evaluate the ambulatory daily glycemic profile in the second half of pregnancy in nondiabetic women. Fifty-seven obese and normal weight nondiabetic subjects were evaluated for 72 consecutive hours with continuous glucose monitoring by measurement interstitial glucose levels in subcutaneous tissue every 5 minutes. Subjects were instructed not to modify their lifestyle or to follow any dietary restriction. For each woman, mean and fasting blood glucose values were determined; for each meal during the study period, the first 180 minutes were analyzed. For the study group, the fasting blood glucose level was 75 ± 12 mg/dL; the mean blood glucose level was 83.7 ± 18 mg/dL; the postprandial peak glucose value level was 110 ± 16 mg/dL, and the time interval that was needed to reach peak postprandial glucose level was 70 ± 13 minutes. A similar postprandial glycemic profile was obtained for breakfast, lunch, and dinner. Obese women were characterized by a significantly higher postprandial glucose peak value, increased 1- and 2-hour postprandial glucose levels, increased time interval for glucose peak, and significantly lower mean blood glucose during the night. No difference was found in fasting and mean blood glucose between obese and nonobese subjects. Glycemic profile characterization in both obese and normal weight nondiabetic subjects provide a measure for the desired level of glycemic control in pregnancy that is complicated with diabetes mellitus.

Original languageEnglish
Pages (from-to)949-953
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume191
Issue number3
DOIs
StatePublished - Sep 2004
Externally publishedYes

Keywords

  • Glycemic profile

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