Disturbances of T lymphocyte subsets preceding refractory anemia with excess blasts in transformation in a child

Arnon Nagler*, Annie Hazani, Amos Etzioni, Ilana Tatarsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A 5-year-old girl with refractory anaemia with excess of blasts in transformation (RAEBT) terminating in acute nonlymphocytic leukemia is reported. The patient’s serum had an inhibitory effect on normal hemopoiesis. T cell subsets defined by monoclonal antibodies revealed a decrease in helper/inducerT cell population (OKT4-positive cells) and inversion of the T4/T8ratio. It is suggested that imbalance in immunoregulatory T cells, which has a crucial role in the control of hemopoiesis, may be a primary event in the pathogenesis of myelodysplastic syndrome which eventually develops into an overt leukemia.

Original languageEnglish
Pages (from-to)103-106
Number of pages4
JournalActa Haematologica
Volume79
Issue number2
DOIs
StatePublished - 1988
Externally publishedYes

Keywords

  • Haemopoiesis
  • Myelodysplastic syndrome
  • T cell subsets

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