Disturbances of T lymphocyte subsets preceding refractory anemia with excess blasts in transformation in a child

Arnon Nagler; Annie Hazani; Amos Etzioni; Ilana Tatarsky

doi:10.1159/000205731

Disturbances of T lymphocyte subsets preceding refractory anemia with excess blasts in transformation in a child

Arnon Nagler^*, Annie Hazani, Amos Etzioni, Ilana Tatarsky

^*Corresponding author for this work

Technion-Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A 5-year-old girl with refractory anaemia with excess of blasts in transformation (RAEBT) terminating in acute nonlymphocytic leukemia is reported. The patient’s serum had an inhibitory effect on normal hemopoiesis. T cell subsets defined by monoclonal antibodies revealed a decrease in helper/inducerT cell population (OKT₄-positive cells) and inversion of the T₄/T₈ratio. It is suggested that imbalance in immunoregulatory T cells, which has a crucial role in the control of hemopoiesis, may be a primary event in the pathogenesis of myelodysplastic syndrome which eventually develops into an overt leukemia.

Original language	English
Pages (from-to)	103-106
Number of pages	4
Journal	Acta Haematologica
Volume	79
Issue number	2
DOIs	https://doi.org/10.1159/000205731
State	Published - 1988
Externally published	Yes

Keywords

Haemopoiesis
Myelodysplastic syndrome
T cell subsets

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10.1159/000205731

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title = "Disturbances of T lymphocyte subsets preceding refractory anemia with excess blasts in transformation in a child",

abstract = "A 5-year-old girl with refractory anaemia with excess of blasts in transformation (RAEBT) terminating in acute nonlymphocytic leukemia is reported. The patient{\textquoteright}s serum had an inhibitory effect on normal hemopoiesis. T cell subsets defined by monoclonal antibodies revealed a decrease in helper/inducerT cell population (OKT4-positive cells) and inversion of the T4/T8ratio. It is suggested that imbalance in immunoregulatory T cells, which has a crucial role in the control of hemopoiesis, may be a primary event in the pathogenesis of myelodysplastic syndrome which eventually develops into an overt leukemia.",

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AU - Hazani, Annie

AU - Etzioni, Amos

AU - Tatarsky, Ilana

PY - 1988

Y1 - 1988

N2 - A 5-year-old girl with refractory anaemia with excess of blasts in transformation (RAEBT) terminating in acute nonlymphocytic leukemia is reported. The patient’s serum had an inhibitory effect on normal hemopoiesis. T cell subsets defined by monoclonal antibodies revealed a decrease in helper/inducerT cell population (OKT4-positive cells) and inversion of the T4/T8ratio. It is suggested that imbalance in immunoregulatory T cells, which has a crucial role in the control of hemopoiesis, may be a primary event in the pathogenesis of myelodysplastic syndrome which eventually develops into an overt leukemia.

AB - A 5-year-old girl with refractory anaemia with excess of blasts in transformation (RAEBT) terminating in acute nonlymphocytic leukemia is reported. The patient’s serum had an inhibitory effect on normal hemopoiesis. T cell subsets defined by monoclonal antibodies revealed a decrease in helper/inducerT cell population (OKT4-positive cells) and inversion of the T4/T8ratio. It is suggested that imbalance in immunoregulatory T cells, which has a crucial role in the control of hemopoiesis, may be a primary event in the pathogenesis of myelodysplastic syndrome which eventually develops into an overt leukemia.

KW - Haemopoiesis

KW - Myelodysplastic syndrome

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Disturbances of T lymphocyte subsets preceding refractory anemia with excess blasts in transformation in a child

Abstract

Keywords

UN SDGs

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