Distribution of serum creatine kinase activity in young healthy persons

Eli I. Lev, Ilan Tur-Kaspa, Isaac Ashkenazy, Anat Reiner, David Faraggi, Joshua Shemer, Zohar Argov*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The normal distribution of serum creatine kinase (CK) was determined in 428 men (mean age=21.5) and 540 women (mean age=20.2). The bootstrap method was employed to obtain statistical parameters of CK reference range and correlations with physical activity habits, BMI, cigarette smoking and alcohol consumption. CK distribution was non-Gaussian and skewed toward the higher values; 18.9% of the men and 4.6% of the women had values above the upper reference limits defined for the commercial assay kit. The median 97.5 percentile value was 532 u/l for men and 248 u/l for women (95% confidence interval of 384-738 u/l and 184-340 u/l, respectively). A significant correlation was found only between CK and alcohol consumption in men. Myoglobin level in a representative group of subjects correlated well with CK activity for both genders. Our findings define the range of CK values in a healthy, young, heterogeneous population. We suggest that only CK levels above the determined 97.5 percentile should warrant further clinical investigation. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)107-115
Number of pages9
JournalClinica Chimica Acta
Issue number1-2
StatePublished - 1 Jan 1999


  • Alcohol
  • BMI
  • Creatine kinase
  • Myoglobin
  • Physical activity


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