@article{b1ee7e0d618d443e8f6e98c108a2c028,
title = "Distribution of fluconazole-resistant Candida bloodstream isolates among hospitals and inpatient services in Israel",
abstract = "The emergence of fluconazole-resistant Candida (FRC) is worrisome, but little is known about susceptibility patterns in different nosocomial settings. We prospectively analysed Candida bloodstream isolates in 18 medical centres in Israel (six tertiary-care and 12 community hospitals). The study included 444 episodes of candidaemia (450 patient-specific isolates, 8.5% fluconazole-resistant). Institutional FRC bloodstream infection rates correlated with annual inpatient days, and were strongly associated with the presence and activity of haematology/oncology services. Infection with Candida krusei and fluconazole-resistant Candida glabrata occurred exclusively in hospitals with >600 beds. These findings suggest that empirical antifungal strategies should be tailored to the nosocomial setting.",
keywords = "Candidaemia, Drug resistance, Epidemiology, Fluconazole",
author = "R. Ben-Ami and G. Rahav and H. Elinav and I. Kassis and I. Shalit and T. Gottesman and O. Megged and M. Weinberger and P. Ciobotaro and P. Shitrit and G. Weber and A. Paz and D. Miron and I. Oren and J. Bishara and C. Block and N. Keller and Kontoyiannis, {D. P.} and M. Giladi",
note = "Funding Information: This work was funded in part by a grant from Merck Sharp & Dohme Ltd, Israel and by the Israeli Society for Infectious Diseases. ",
year = "2013",
month = aug,
doi = "10.1111/1469-0691.12004",
language = "אנגלית",
volume = "19",
pages = "752--756",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Elsevier Ltd.",
number = "8",
}